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- W2013480118 abstract "A novel technique of lithotripsy was investigated with amid-infrared tunable pulsed laser using difference-frequency generation (DFG).Human gallstone samples obtained from 24 patients were analyzed with theirinfrared absorption spectra. It was found that the principal components of thegallstones were different for the different patients and that the gallstonesamples used in this research could be classified into four groups, i.e., mixed stones, calcium bilirubinatestones, cholesterol stones, and calcium carbonate stones. In addition, somegallstone samples had different compositions within the single stone. Themid-infrared laser tunable within a wavelength range of 5.5 - 10 μm wasirradiated to the cholesterol stones at two different wavelengths of 6.83 and6.03 μm, where the cholesterol stones had relatively strong and weak absorptionpeaks, respectively. As the result, the cholesterol stones were moreefficiently ablated at the wavelength of 6.83 μm with the strong absorptionpeak. Therefore, it is suggested that the gallstones could be efficiently ablatedby tuning the wavelength of the laser to the strong absorption peak of thegallstones. The higher efficiency of the ablation using the characteristicabsorption peaks should lead to the safer treatment without damage to thesurrounding normal tissues. In order to identify the composition of thegallstones in the patients, endoscopic and spectroscopic diagnosis using theDFG laser and an optical fiber probe made with two hollow optical fibers and adiamond attenuation total reflection prism should be useful. The absorptionspectrum of the gallstones in the patients could be measured by measuring theenergy of the DFG laser transmitted through the optical fiber probe and byscanning the wavelength of the DFG laser." @default.
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- W2013480118 date "2013-01-01" @default.
- W2013480118 modified "2023-10-01" @default.
- W2013480118 title "Mid-Infrared Pulsed Laser Lithotripsy with a Tunable Laser Using Difference-Frequency Generation" @default.
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- W2013480118 doi "https://doi.org/10.4236/opj.2013.34a002" @default.
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