FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013484908> ?p ?o ?g. }

• W2013484908 endingPage "227" @default.
• W2013484908 startingPage "214" @default.
• W2013484908 abstract "Methods to increase the development and sustained function of embryonic mesencephalic dopamine cells after transplantation into dopamine (DA)-depleted striatum are currently under investigation. Elements that are crucial for the maturation and connectivity of neurons during normal development of the brain may also play a role in the development and integration of grafted embryonic tissue. Based onin vitroandin vivoobservations of the enhancing effects of striatal tissue on nigral dopaminergic cell development and survival, we demonstrate that inclusion of embryonic striatal cells, specifically from the lateral ganglionic eminence (LGE), produces dopaminergic transplants with augmented functional effects. Rats neonatally DA-depleted and co-transplanted with embryonic nigral and LGE cells developed improved functional outcome when compared with animals receiving only nigral cells, and they required the transplantation of fewer nigral cells to produce a strong behavioral effect. Anatomically, the inclusion of LGE cells produced increased DA cell survival, a higher density of reinnervation into the DA-depleted host striatum, and patches of DA fibers within the co-transplants. There were also an increased number of host striatal cells which induced the immediate-early gene c-fos in co-transplanted animals compared to animals receiving nigral cells alone, indicating a higher degree of host-cell activation. The ability to enhance function, cell survival, reinnervation, and host activation with nigral-striatal co-transplants in the presence of fewer nigral cells supports the hypothesis of a trophic influence of striatal cells on nigral DA cells." @default.
• W2013484908 created "2016-06-24" @default.
• W2013484908 creator A5001687497 @default.
• W2013484908 creator A5046825617 @default.
• W2013484908 date "1997-05-01" @default.
• W2013484908 modified "2023-09-27" @default.
• W2013484908 title "Co-transplantation of Fetal Lateral Ganglionic Eminence and Ventral Mesencephalon Can Augment Function and Development of Intrastriatal Transplants" @default.
• W2013484908 cites W1758480227 @default.
• W2013484908 cites W1857800496 @default.
• W2013484908 cites W1967533184 @default.
• W2013484908 cites W1967988079 @default.
• W2013484908 cites W1968084077 @default.
• W2013484908 cites W1969189715 @default.
• W2013484908 cites W1970979709 @default.
• W2013484908 cites W1972830080 @default.
• W2013484908 cites W1973847302 @default.
• W2013484908 cites W1977801073 @default.
• W2013484908 cites W1982533391 @default.
• W2013484908 cites W1986956130 @default.
• W2013484908 cites W1990654593 @default.
• W2013484908 cites W1991556375 @default.
• W2013484908 cites W1995658302 @default.
• W2013484908 cites W1996800446 @default.
• W2013484908 cites W1996835488 @default.
• W2013484908 cites W1998060288 @default.
• W2013484908 cites W2000959222 @default.
• W2013484908 cites W2005487930 @default.
• W2013484908 cites W2005657014 @default.
• W2013484908 cites W2007231943 @default.
• W2013484908 cites W2007472184 @default.
• W2013484908 cites W2008900902 @default.
• W2013484908 cites W2009302659 @default.
• W2013484908 cites W2011262181 @default.
• W2013484908 cites W2015500392 @default.
• W2013484908 cites W2019834805 @default.
• W2013484908 cites W2027724821 @default.
• W2013484908 cites W2028442574 @default.
• W2013484908 cites W2029235596 @default.
• W2013484908 cites W2030939346 @default.
• W2013484908 cites W2036564942 @default.
• W2013484908 cites W2036947513 @default.
• W2013484908 cites W2041981462 @default.
• W2013484908 cites W2042895504 @default.
• W2013484908 cites W2047093858 @default.
• W2013484908 cites W2050495437 @default.
• W2013484908 cites W2054810445 @default.
• W2013484908 cites W2058601367 @default.
• W2013484908 cites W2059095709 @default.
• W2013484908 cites W2060085557 @default.
• W2013484908 cites W2060924375 @default.
• W2013484908 cites W2062480445 @default.
• W2013484908 cites W2063300711 @default.
• W2013484908 cites W2064521170 @default.
• W2013484908 cites W2067920906 @default.
• W2013484908 cites W2069327229 @default.
• W2013484908 cites W2073671033 @default.
• W2013484908 cites W2075509664 @default.
• W2013484908 cites W2076010559 @default.
• W2013484908 cites W2079347869 @default.
• W2013484908 cites W2080875310 @default.
• W2013484908 cites W2081291008 @default.
• W2013484908 cites W2085285204 @default.
• W2013484908 cites W2085773003 @default.
• W2013484908 cites W2086927501 @default.
• W2013484908 cites W2091392612 @default.
• W2013484908 cites W2107486301 @default.
• W2013484908 cites W2119148931 @default.
• W2013484908 cites W2157381594 @default.
• W2013484908 cites W2158649743 @default.
• W2013484908 cites W2318463768 @default.
• W2013484908 cites W2326829941 @default.
• W2013484908 cites W2469126284 @default.
• W2013484908 cites W2764740849 @default.
• W2013484908 cites W370545499 @default.
• W2013484908 cites W949920693 @default.
• W2013484908 doi "https://doi.org/10.1006/exnr.1997.6477" @default.
• W2013484908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9184123" @default.
• W2013484908 hasPublicationYear "1997" @default.
• W2013484908 type Work @default.
• W2013484908 sameAs 2013484908 @default.
• W2013484908 citedByCount "24" @default.
• W2013484908 countsByYear W20134849082013 @default.
• W2013484908 crossrefType "journal-article" @default.
• W2013484908 hasAuthorship W2013484908A5001687497 @default.
• W2013484908 hasAuthorship W2013484908A5046825617 @default.
• W2013484908 hasConcept C104317684 @default.
• W2013484908 hasConcept C126322002 @default.
• W2013484908 hasConcept C137183658 @default.
• W2013484908 hasConcept C145103041 @default.
• W2013484908 hasConcept C169760540 @default.
• W2013484908 hasConcept C2779649809 @default.
• W2013484908 hasConcept C2780062018 @default.
• W2013484908 hasConcept C2780597806 @default.
• W2013484908 hasConcept C2780938664 @default.
• W2013484908 hasConcept C2911091166 @default.
• W2013484908 hasConcept C513476851 @default.
• W2013484908 hasConcept C529278444 @default.
• W2013484908 hasConcept C533869091 @default.

• next