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- W2013488721 abstract "While the precise function of CD8αα homodimer expression on peripheral T cells is uncertain, recent evidence indicates that it facilitates survival and differentiation of lymphocytic choriomeningitis virus (LCMV)-specific memory CD8αβ T cell precursors in vivo. Here, we show that the CD8αα homodimer is also transiently up-regulated on influenza A virus-specific CD8αβ T cells after infection in vivo, temporally correlating with increased levels of the memory T cell development- and survival-related molecules IL-7Rα and Bcl-2, respectively. Unlike with LCMV, however, deletion of the CD8αα enhancer I does not abrogate CD8αα homodimer expression or manifest a significant impact on the generation of virus-specific, functional effector and central memory T cells in influenza A virus infection. These results demonstrate that the role of CD8αα in the generation of antiviral CD8 T cell memory is complex, presumably because various viral stimuli differentially regulate CD8αα expression. Further studies are needed to define those ligands that induce CD8αα on T cells during acute viral infections, and the general relevance of this process to memory T cell formation. See accompanying commentary: http://dx.doi.org/10.1002/eji.200535516" @default.
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- W2013488721 date "2005-11-01" @default.
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- W2013488721 title "CD8αα homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice" @default.
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- W2013488721 doi "https://doi.org/10.1002/eji.200535162" @default.
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