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- W2013493322 abstract "Abstract To understand the toxic effects and conflicting reports of aloin and aloe-emodin, we investigated their antioxidant and prooxidant effects on free radical-induced DNA breaks over a wide range of concentrations. Aloin, at concentrations ranging from 1.25 to 2.5 mM, prevented OH-induced DNA breaks by 5–30% over control values. In contrast, addition of aloin at lower concentrations (8–300 μM) increased DNA damage by about 24–74%, indicating its prooxidant effect. Aloe-emodin showed little antioxidant effect at any tested concentration, but addition of higher concentrations (1.25–2.5 mM) of aloe-emodin had a prooxidant effect on DNA (about 29–35%). The greater reducing activity of aloin at low concentrations, reducing Fe 3+ to Fe 2+ , which enhanced the generation of OH from the Fenton reaction, may play a key role in its prooxidant effect on DNA. At higher concentrations, however, free radical-scavenging activity of aloin gradually predominated over its reducing power, resulting in the protection of DNA. Predomination of reducing power over scavenging activity resulted in the prooxidant effect of aloe-emodin at high concentrations. The relationship between structures and anti- or pro-oxidant effects of aloin and aloe-emodin is also discussed." @default.
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- W2013493322 date "2005-07-01" @default.
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- W2013493322 title "Concentration-dependence of prooxidant and antioxidant effects of aloin and aloe-emodin on DNA" @default.
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- W2013493322 doi "https://doi.org/10.1016/j.foodchem.2004.06.018" @default.
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