Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013498384> ?p ?o ?g. }
- W2013498384 abstract "The calcium-sensing receptor (CaSR) is expressed abundantly in normal colonic epithelium and lost in colon cancer, but its exact role on a molecular level and within the carcinogenesis pathway is yet to be described. Epidemiologic studies show that inadequate dietary calcium predisposes to colon cancer; this may be due to the ability of calcium to bind and upregulate the CaSR. Loss of CaSR expression does not seem to be an early event in carcinogenesis; indeed it is associated with late stage, poorly differentiated, chemo-resistant tumors. Induction of CaSR expression in neoplastic colonocytes arrests tumor progression and deems tumors more sensitive to chemotherapy; hence CaSR may be an important target in colon cancer treatment. The CaSR has a complex role in colon cancer; however, more investigation is required on a molecular level to clarify its exact function in carcinogenesis. This review describes the mechanisms by which the CaSR is currently implicated in colon cancer and identifies areas where further study is needed." @default.
- W2013498384 created "2016-06-24" @default.
- W2013498384 creator A5056246938 @default.
- W2013498384 creator A5075032748 @default.
- W2013498384 creator A5085025614 @default.
- W2013498384 creator A5086987015 @default.
- W2013498384 creator A5091845879 @default.
- W2013498384 date "2012-03-01" @default.
- W2013498384 modified "2023-09-25" @default.
- W2013498384 title "Review Article: Loss of the Calcium-Sensing Receptor in Colonic Epithelium is a Key Event in the Pathogenesis of Colon Cancer" @default.
- W2013498384 cites W143805906 @default.
- W2013498384 cites W1650401181 @default.
- W2013498384 cites W1666469474 @default.
- W2013498384 cites W1969928750 @default.
- W2013498384 cites W1969950007 @default.
- W2013498384 cites W1972964586 @default.
- W2013498384 cites W1981000910 @default.
- W2013498384 cites W1983118346 @default.
- W2013498384 cites W1984229392 @default.
- W2013498384 cites W1987008602 @default.
- W2013498384 cites W1991566203 @default.
- W2013498384 cites W1995638940 @default.
- W2013498384 cites W1998194364 @default.
- W2013498384 cites W1998761065 @default.
- W2013498384 cites W2003554564 @default.
- W2013498384 cites W2003791200 @default.
- W2013498384 cites W2009441758 @default.
- W2013498384 cites W2018556023 @default.
- W2013498384 cites W2020851497 @default.
- W2013498384 cites W2021826993 @default.
- W2013498384 cites W2023517521 @default.
- W2013498384 cites W2024774687 @default.
- W2013498384 cites W2034653788 @default.
- W2013498384 cites W2036995355 @default.
- W2013498384 cites W2041380953 @default.
- W2013498384 cites W2043666480 @default.
- W2013498384 cites W2047322151 @default.
- W2013498384 cites W2049907597 @default.
- W2013498384 cites W2051650083 @default.
- W2013498384 cites W2060962205 @default.
- W2013498384 cites W2061028210 @default.
- W2013498384 cites W2065133740 @default.
- W2013498384 cites W2076383347 @default.
- W2013498384 cites W2077965603 @default.
- W2013498384 cites W2079054436 @default.
- W2013498384 cites W2079444371 @default.
- W2013498384 cites W2094281679 @default.
- W2013498384 cites W2095150828 @default.
- W2013498384 cites W2097199943 @default.
- W2013498384 cites W2101319242 @default.
- W2013498384 cites W2103403969 @default.
- W2013498384 cites W2106856165 @default.
- W2013498384 cites W2109484905 @default.
- W2013498384 cites W2118913969 @default.
- W2013498384 cites W2127341411 @default.
- W2013498384 cites W2130359015 @default.
- W2013498384 cites W2134468948 @default.
- W2013498384 cites W2137196921 @default.
- W2013498384 cites W2150354198 @default.
- W2013498384 cites W2150639379 @default.
- W2013498384 cites W2152879728 @default.
- W2013498384 cites W2157740198 @default.
- W2013498384 cites W2315674654 @default.
- W2013498384 cites W2319963574 @default.
- W2013498384 cites W2467824185 @default.
- W2013498384 cites W4255218637 @default.
- W2013498384 doi "https://doi.org/10.1016/j.clcc.2011.04.003" @default.
- W2013498384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21723793" @default.
- W2013498384 hasPublicationYear "2012" @default.
- W2013498384 type Work @default.
- W2013498384 sameAs 2013498384 @default.
- W2013498384 citedByCount "28" @default.
- W2013498384 countsByYear W20134983842012 @default.
- W2013498384 countsByYear W20134983842013 @default.
- W2013498384 countsByYear W20134983842014 @default.
- W2013498384 countsByYear W20134983842016 @default.
- W2013498384 countsByYear W20134983842017 @default.
- W2013498384 countsByYear W20134983842018 @default.
- W2013498384 countsByYear W20134983842020 @default.
- W2013498384 countsByYear W20134983842021 @default.
- W2013498384 countsByYear W20134983842022 @default.
- W2013498384 countsByYear W20134983842023 @default.
- W2013498384 crossrefType "journal-article" @default.
- W2013498384 hasAuthorship W2013498384A5056246938 @default.
- W2013498384 hasAuthorship W2013498384A5075032748 @default.
- W2013498384 hasAuthorship W2013498384A5085025614 @default.
- W2013498384 hasAuthorship W2013498384A5086987015 @default.
- W2013498384 hasAuthorship W2013498384A5091845879 @default.
- W2013498384 hasConcept C104317684 @default.
- W2013498384 hasConcept C121608353 @default.
- W2013498384 hasConcept C126322002 @default.
- W2013498384 hasConcept C127561419 @default.
- W2013498384 hasConcept C142590548 @default.
- W2013498384 hasConcept C143998085 @default.
- W2013498384 hasConcept C2780942790 @default.
- W2013498384 hasConcept C502942594 @default.
- W2013498384 hasConcept C519063684 @default.
- W2013498384 hasConcept C526805850 @default.
- W2013498384 hasConcept C55493867 @default.
- W2013498384 hasConcept C555283112 @default.