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- W2013500302 abstract "<h3>Objective:</h3> To investigate the effects of neutrophil (PMN) transmigration into inflammatory sites on cytosolic pH (pH<sub>i</sub>) regulation. <h3>Design:</h3> Exudative PMNs were obtained by bronchoalveolar lavage from rats sustaining endotoxin-induced lung injury. Circulating PMNs were purified with density-gradient centrifugation. Cytosolic pH was measured with single-cell fluorescence imaging using the pH-sensitive dye biscarboxyethyl-carboxyfluorescein. <h3>Results:</h3> Exudative PMNs showed impaired pH, recovery from an induced acid load compared with circulating PMNs. Under conditions of extracellular acidosis, exudative PMNs showed impaired pH<sub>i</sub>homeostasis and produced decreased superoxide compared with circulating cells. Inhibition of the sodiumproton exchanger attenuated the differences in pH<sub>i</sub>recovery, suggesting a mechanism underlying the pH<sub>i</sub>regulatory dysfunction. All cells had comparable adenosine triphosphate levels and superoxide production at physiologic extracellular pH. <h3>Conclusion:</h3> Impaired pH, regulation of exudative cells may mediate cellular dysfunction and impaired resolution of infection at inflammatory sites. Arch Surg. 1996;131:1296-1301" @default.
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- W2013500302 date "1996-12-01" @default.
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- W2013500302 title "Exudative Neutrophils Show Impaired pH Regulation Compared With Circulating Neutrophils" @default.
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- W2013500302 doi "https://doi.org/10.1001/archsurg.1996.01430240050006" @default.
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