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• W2013500571 abstract "One major challenge to human cancer gene therapy, is efficient delivery of the gene-vector complex.Using two distinct human nasopharyngeal carcinoma (NPC) models, we demonstrate that intra-tumoural (IT) administration of adenoviral-mediated wild-type p53 gene therapy (Ad-p53) caused no greater inhibition of tumour growth as compared to ionizing radiation (XRT) alone. Detailed histologic examination of tumour sections demonstrated that <15% of tumour cells were transduced by IT adv-beta-gal.This report underscores the importance of developing gene transfer vectors, which can provide therapeutic levels of transgene expression efficiently in solid tumours." @default.
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• W2013500571 date "2001-12-01" @default.
• W2013500571 modified "2023-09-23" @default.
• W2013500571 title "Adenovirus-p53 gene therapy in human nasopharyngeal carcinoma xenografts" @default.
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• W2013500571 doi "https://doi.org/10.1016/s0167-8140(01)00398-x" @default.
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