Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013502712> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2013502712 endingPage "176" @default.
- W2013502712 startingPage "168" @default.
- W2013502712 abstract "The binding of [G-3H]nitrobenzylthioinosine to intact Chinese hamster ovary cells has been studied kinetically and thermodynamically. The association of nitrobenzylthioinosine with cells is a second-order process which proceeds at 24°C with a rate constant of 2·107 M−1·s−1. Dissociation of the complex was characterized as a simple first-order process with rate constant on the order of 7·10−3 s−1. The quotient of these is comparable to the dissociation constant as measured in equilibrium binding studies, 2.2·10−10 M. The temperature dependence of the rate of association indicated an Arrhenius activation energy of 8.4 kcal·mol−1, while that of the equilibrium constant for dissociation indicated a standard enthalpy change of 8.8 kcal·mol−1. The large increase in affinity of nitrobenzylthioinosine as compared to natural nucleosides is attributable to an entropy-driven interaction with the binding site. Thymidine, dipyridamole and papaverine each decrease the apparent dissociation constant for the nitrobenzylthioinosine-cell complex; the latter, inhibitors of nucleoside transport, decrease the rate of dissociation of the complex." @default.
- W2013502712 created "2016-06-24" @default.
- W2013502712 creator A5029191248 @default.
- W2013502712 creator A5032099014 @default.
- W2013502712 creator A5060119566 @default.
- W2013502712 date "1983-06-01" @default.
- W2013502712 modified "2023-09-25" @default.
- W2013502712 title "Kinetic and thermodynamic studies on nitrobenzylthioinosine binding to the nucleoside transporter of chinese hamster ovary cells" @default.
- W2013502712 cites W1029653837 @default.
- W2013502712 cites W1533220703 @default.
- W2013502712 cites W1644370209 @default.
- W2013502712 cites W1687021633 @default.
- W2013502712 cites W1709825267 @default.
- W2013502712 cites W1975584525 @default.
- W2013502712 cites W1979152909 @default.
- W2013502712 cites W1980559044 @default.
- W2013502712 cites W1993159084 @default.
- W2013502712 cites W2014299753 @default.
- W2013502712 cites W2014940468 @default.
- W2013502712 cites W2018781275 @default.
- W2013502712 cites W2022192917 @default.
- W2013502712 cites W2045651800 @default.
- W2013502712 cites W2074333534 @default.
- W2013502712 cites W2203879728 @default.
- W2013502712 cites W2338410375 @default.
- W2013502712 cites W3906723 @default.
- W2013502712 doi "https://doi.org/10.1016/0005-2736(83)90006-8" @default.
- W2013502712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6849914" @default.
- W2013502712 hasPublicationYear "1983" @default.
- W2013502712 type Work @default.
- W2013502712 sameAs 2013502712 @default.
- W2013502712 citedByCount "27" @default.
- W2013502712 countsByYear W20135027122012 @default.
- W2013502712 countsByYear W20135027122023 @default.
- W2013502712 crossrefType "journal-article" @default.
- W2013502712 hasAuthorship W2013502712A5029191248 @default.
- W2013502712 hasAuthorship W2013502712A5032099014 @default.
- W2013502712 hasAuthorship W2013502712A5060119566 @default.
- W2013502712 hasConcept C102931765 @default.
- W2013502712 hasConcept C104317684 @default.
- W2013502712 hasConcept C10710636 @default.
- W2013502712 hasConcept C121332964 @default.
- W2013502712 hasConcept C147789679 @default.
- W2013502712 hasConcept C148898269 @default.
- W2013502712 hasConcept C149011108 @default.
- W2013502712 hasConcept C170493617 @default.
- W2013502712 hasConcept C175656101 @default.
- W2013502712 hasConcept C185592680 @default.
- W2013502712 hasConcept C2776543447 @default.
- W2013502712 hasConcept C2780549722 @default.
- W2013502712 hasConcept C3288061 @default.
- W2013502712 hasConcept C55493867 @default.
- W2013502712 hasConcept C62520636 @default.
- W2013502712 hasConcept C71240020 @default.
- W2013502712 hasConcept C74998103 @default.
- W2013502712 hasConcept C93391505 @default.
- W2013502712 hasConcept C97355855 @default.
- W2013502712 hasConceptScore W2013502712C102931765 @default.
- W2013502712 hasConceptScore W2013502712C104317684 @default.
- W2013502712 hasConceptScore W2013502712C10710636 @default.
- W2013502712 hasConceptScore W2013502712C121332964 @default.
- W2013502712 hasConceptScore W2013502712C147789679 @default.
- W2013502712 hasConceptScore W2013502712C148898269 @default.
- W2013502712 hasConceptScore W2013502712C149011108 @default.
- W2013502712 hasConceptScore W2013502712C170493617 @default.
- W2013502712 hasConceptScore W2013502712C175656101 @default.
- W2013502712 hasConceptScore W2013502712C185592680 @default.
- W2013502712 hasConceptScore W2013502712C2776543447 @default.
- W2013502712 hasConceptScore W2013502712C2780549722 @default.
- W2013502712 hasConceptScore W2013502712C3288061 @default.
- W2013502712 hasConceptScore W2013502712C55493867 @default.
- W2013502712 hasConceptScore W2013502712C62520636 @default.
- W2013502712 hasConceptScore W2013502712C71240020 @default.
- W2013502712 hasConceptScore W2013502712C74998103 @default.
- W2013502712 hasConceptScore W2013502712C93391505 @default.
- W2013502712 hasConceptScore W2013502712C97355855 @default.
- W2013502712 hasIssue "2" @default.
- W2013502712 hasLocation W20135027121 @default.
- W2013502712 hasLocation W20135027122 @default.
- W2013502712 hasOpenAccess W2013502712 @default.
- W2013502712 hasPrimaryLocation W20135027121 @default.
- W2013502712 hasRelatedWork W1970782840 @default.
- W2013502712 hasRelatedWork W1976580976 @default.
- W2013502712 hasRelatedWork W2013502712 @default.
- W2013502712 hasRelatedWork W2022160160 @default.
- W2013502712 hasRelatedWork W2022680788 @default.
- W2013502712 hasRelatedWork W2026983232 @default.
- W2013502712 hasRelatedWork W2046266903 @default.
- W2013502712 hasRelatedWork W2170164067 @default.
- W2013502712 hasRelatedWork W2360607682 @default.
- W2013502712 hasRelatedWork W4242836331 @default.
- W2013502712 hasVolume "731" @default.
- W2013502712 isParatext "false" @default.
- W2013502712 isRetracted "false" @default.
- W2013502712 magId "2013502712" @default.
- W2013502712 workType "article" @default.