FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013502986> ?p ?o ?g. }

• W2013502986 endingPage "830" @default.
• W2013502986 startingPage "826" @default.
• W2013502986 abstract "Three immunoreactive forms of PRL, separated by Sephadex G-100 column chromatography, were identified in serum samples from 10 normal subjects and 7 patients with PRL-secreting pituitary tumors. Fractions eluted from the column were assayed for bioactivity by using a sensitive bioassay with the Nb2 cell line. Three molecular weight variants of PRL were identified in normal subjects. In samples from 9 of the 10 normal subjects, 80.1 +/- 3.6% (mean +/- SEM) of the total bioactivity eluted in a peak corresponding to a PRL monomer (peak III) with a mol wt of approximately 24,000, 18.3 +/- 3.7% eluted in a peak with a mol wt of approximately 56,000 (peak II), and 1.6 +/- 1.1% of the biological activity was in the void volume (peak I). In the 10th normal sample, 65% of the total bioactivity was in the void volume (peak I), 31% was in peak III, and 4% was in peak II. Samples from the patients had 3.6 +/- 0.7% of the total bioactivity in peak I, 9.3 +/- 1.0% in peak II, and 87.0 +/- 1.1% in peak III, percentages not significantly different from normal. For comparison with bioassay, RIA measurement of PRL was performed on all fractions of six samples (three normal subjects and three tumor patients). Good correlation was found between RIA and bioassay measurements under each of the three peaks identified. We conclude that 1) in sera from normal subjects, three molecular weight variants of PRL have biological activity; 2) in patients with PRL-secreting tumors, secretion of biologically active PRL molecular weight variants is not proportionately different from that in normal subjects; and 3) the results of the Nb2 PRL bioassay correlate well with PRL levels determined by RIA for each of three molecular weight variants identified." @default.
• W2013502986 created "2016-06-24" @default.
• W2013502986 creator A5030546248 @default.
• W2013502986 creator A5032071150 @default.
• W2013502986 creator A5080742714 @default.
• W2013502986 creator A5085272325 @default.
• W2013502986 creator A5086598720 @default.
• W2013502986 date "1984-05-01" @default.
• W2013502986 modified "2023-09-27" @default.
• W2013502986 title "Demonstration of Biological Activity of Prolactin Molecular Weight Variants in Human Sera*" @default.
• W2013502986 cites W1936334979 @default.
• W2013502986 cites W1992020758 @default.
• W2013502986 cites W2008892986 @default.
• W2013502986 cites W2039304568 @default.
• W2013502986 cites W2063989432 @default.
• W2013502986 cites W2066110109 @default.
• W2013502986 cites W2076027242 @default.
• W2013502986 cites W2086091710 @default.
• W2013502986 cites W2092807413 @default.
• W2013502986 cites W2105402802 @default.
• W2013502986 cites W2119238166 @default.
• W2013502986 cites W2132134321 @default.
• W2013502986 cites W2148484073 @default.
• W2013502986 cites W2152986928 @default.
• W2013502986 cites W2327767900 @default.
• W2013502986 cites W2441515707 @default.
• W2013502986 cites W59511522 @default.
• W2013502986 doi "https://doi.org/10.1210/jcem-58-5-826" @default.
• W2013502986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6707188" @default.
• W2013502986 hasPublicationYear "1984" @default.
• W2013502986 type Work @default.
• W2013502986 sameAs 2013502986 @default.
• W2013502986 citedByCount "63" @default.
• W2013502986 countsByYear W20135029862012 @default.
• W2013502986 countsByYear W20135029862013 @default.
• W2013502986 countsByYear W20135029862014 @default.
• W2013502986 countsByYear W20135029862019 @default.
• W2013502986 countsByYear W20135029862022 @default.
• W2013502986 countsByYear W20135029862023 @default.
• W2013502986 crossrefType "journal-article" @default.
• W2013502986 hasAuthorship W2013502986A5030546248 @default.
• W2013502986 hasAuthorship W2013502986A5032071150 @default.
• W2013502986 hasAuthorship W2013502986A5080742714 @default.
• W2013502986 hasAuthorship W2013502986A5085272325 @default.
• W2013502986 hasAuthorship W2013502986A5086598720 @default.
• W2013502986 hasConcept C104488531 @default.
• W2013502986 hasConcept C116073593 @default.
• W2013502986 hasConcept C124815738 @default.
• W2013502986 hasConcept C126322002 @default.
• W2013502986 hasConcept C134018914 @default.
• W2013502986 hasConcept C163994747 @default.
• W2013502986 hasConcept C176685330 @default.
• W2013502986 hasConcept C179998833 @default.
• W2013502986 hasConcept C181199279 @default.
• W2013502986 hasConcept C185592680 @default.
• W2013502986 hasConcept C202751555 @default.
• W2013502986 hasConcept C2779064019 @default.
• W2013502986 hasConcept C43617362 @default.
• W2013502986 hasConcept C54355233 @default.
• W2013502986 hasConcept C55493867 @default.
• W2013502986 hasConcept C58121356 @default.
• W2013502986 hasConcept C71315377 @default.
• W2013502986 hasConcept C71924100 @default.
• W2013502986 hasConcept C73826308 @default.
• W2013502986 hasConcept C86803240 @default.
• W2013502986 hasConceptScore W2013502986C104488531 @default.
• W2013502986 hasConceptScore W2013502986C116073593 @default.
• W2013502986 hasConceptScore W2013502986C124815738 @default.
• W2013502986 hasConceptScore W2013502986C126322002 @default.
• W2013502986 hasConceptScore W2013502986C134018914 @default.
• W2013502986 hasConceptScore W2013502986C163994747 @default.
• W2013502986 hasConceptScore W2013502986C176685330 @default.
• W2013502986 hasConceptScore W2013502986C179998833 @default.
• W2013502986 hasConceptScore W2013502986C181199279 @default.
• W2013502986 hasConceptScore W2013502986C185592680 @default.
• W2013502986 hasConceptScore W2013502986C202751555 @default.
• W2013502986 hasConceptScore W2013502986C2779064019 @default.
• W2013502986 hasConceptScore W2013502986C43617362 @default.
• W2013502986 hasConceptScore W2013502986C54355233 @default.
• W2013502986 hasConceptScore W2013502986C55493867 @default.
• W2013502986 hasConceptScore W2013502986C58121356 @default.
• W2013502986 hasConceptScore W2013502986C71315377 @default.
• W2013502986 hasConceptScore W2013502986C71924100 @default.
• W2013502986 hasConceptScore W2013502986C73826308 @default.
• W2013502986 hasConceptScore W2013502986C86803240 @default.
• W2013502986 hasIssue "5" @default.
• W2013502986 hasLocation W20135029861 @default.
• W2013502986 hasLocation W20135029862 @default.
• W2013502986 hasOpenAccess W2013502986 @default.
• W2013502986 hasPrimaryLocation W20135029861 @default.
• W2013502986 hasRelatedWork W2013502986 @default.
• W2013502986 hasRelatedWork W2024485952 @default.
• W2013502986 hasRelatedWork W2037142213 @default.
• W2013502986 hasRelatedWork W2042426210 @default.
• W2013502986 hasRelatedWork W2043105234 @default.
• W2013502986 hasRelatedWork W2067134952 @default.
• W2013502986 hasRelatedWork W2078253846 @default.
• W2013502986 hasRelatedWork W2153052119 @default.

• next