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- W2013503880 abstract "The CD40 molecule transmits a signal that abrogates apoptosis induced by ligation of the antigen receptor (BCR) in both primary B cells and B-cell lines such as WEHI-231. Expression of Bcl-xL and A1, antiapoptotic members of the Bcl-2 family, is enhanced by CD40 ligation, and is suggested to mediate CD40-induced B-cell survival. CD40 ligation also promotes cell cycle progression by increasing the levels of cyclin-dependent kinases (CDKs) required for cell cycle progression, and reducing expression of the CDK inhibitor p27kip1. Here we demonstrate that cell cycle inhibition by retrovirus-mediated p27kip1 expression does not modulate the levels of Bcl-xL or A1, but significantly reduces the survival of BCR-ligated WEHI-231 cells by CD40 ligation. This indicates that cell cycle progression is crucial for CD40-mediated survival of B cells." @default.
- W2013503880 created "2016-06-24" @default.
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- W2013503880 date "2003-11-28" @default.
- W2013503880 modified "2023-10-13" @default.
- W2013503880 title "Involvement of cell cycle progression in survival signaling through CD40 in the B-lymphocyte line WEHI-231" @default.
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- W2013503880 doi "https://doi.org/10.1038/sj.cdd.4401357" @default.
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