Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013504920> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2013504920 endingPage "538" @default.
- W2013504920 startingPage "531" @default.
- W2013504920 abstract "Mercury is a global pollutant considered to be a persistent bioaccumulative and toxic chemical. Humans may be exposed to organic forms of mercury by either inhalation, oral, or dermal routes. Methylmercury is more toxic to living organisms than the inorganic forms. In this study, we attempted to elucidate the altered functions of alveolar macrophage including nitric oxide production after methylmercury exposure. Treatment of 7 μM methylmercury for 24 h inhibited lipopolysaccharide-induced nitric oxide and nitric oxide synthase production of alveolar macrophages. The addition of H-89 (PKA inhibitor) significantly decreased the methylmercury inhibition of lipopolysaccharide-mediated nitric oxide production. We found the cell had a calcium-dependent adenylate cyclase, and MeHg could inhibit the phosphorylation of extracellular-signal regulated kinase (ERK). Because methylmercury could increase the intracellular calcium ion concentration, it might activate the adenylate cyclase by increasing [Ca 2+ ] i . Though the interaction of methylmercury with the immune system has been studied by several investigators, the actual mechanisms underlying these interactions are still poorly understood. We discovered that methylmercury could activate protein kinase A, which in turn would inhibit the activation of Raf-1-ERK and so inhibit the release of nitric oxide." @default.
- W2013504920 created "2016-06-24" @default.
- W2013504920 creator A5034970215 @default.
- W2013504920 date "2008-09-01" @default.
- W2013504920 modified "2023-09-25" @default.
- W2013504920 title "The influence of methylmercury on the nitric oxide production of alveolar macrophages" @default.
- W2013504920 cites W1571882069 @default.
- W2013504920 cites W1893715971 @default.
- W2013504920 cites W1964428482 @default.
- W2013504920 cites W1968366393 @default.
- W2013504920 cites W1975607568 @default.
- W2013504920 cites W1986812906 @default.
- W2013504920 cites W1993876642 @default.
- W2013504920 cites W1998228104 @default.
- W2013504920 cites W1999838168 @default.
- W2013504920 cites W2007701411 @default.
- W2013504920 cites W2008232894 @default.
- W2013504920 cites W2009089985 @default.
- W2013504920 cites W2009691874 @default.
- W2013504920 cites W2010605320 @default.
- W2013504920 cites W2014285045 @default.
- W2013504920 cites W2028405924 @default.
- W2013504920 cites W2045876058 @default.
- W2013504920 cites W2048281880 @default.
- W2013504920 cites W2049338606 @default.
- W2013504920 cites W2062523468 @default.
- W2013504920 cites W2064504141 @default.
- W2013504920 cites W2070906364 @default.
- W2013504920 cites W2081515380 @default.
- W2013504920 cites W2083714652 @default.
- W2013504920 cites W2087082909 @default.
- W2013504920 cites W2110614042 @default.
- W2013504920 cites W2118557125 @default.
- W2013504920 cites W2119932283 @default.
- W2013504920 cites W2130660420 @default.
- W2013504920 cites W2134993428 @default.
- W2013504920 cites W2159994767 @default.
- W2013504920 cites W2179702494 @default.
- W2013504920 cites W54129781 @default.
- W2013504920 doi "https://doi.org/10.1177/0748233708098122" @default.
- W2013504920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19039081" @default.
- W2013504920 hasPublicationYear "2008" @default.
- W2013504920 type Work @default.
- W2013504920 sameAs 2013504920 @default.
- W2013504920 citedByCount "10" @default.
- W2013504920 countsByYear W20135049202012 @default.
- W2013504920 countsByYear W20135049202014 @default.
- W2013504920 countsByYear W20135049202018 @default.
- W2013504920 countsByYear W20135049202019 @default.
- W2013504920 countsByYear W20135049202021 @default.
- W2013504920 crossrefType "journal-article" @default.
- W2013504920 hasAuthorship W2013504920A5034970215 @default.
- W2013504920 hasConcept C107872376 @default.
- W2013504920 hasConcept C134018914 @default.
- W2013504920 hasConcept C178790620 @default.
- W2013504920 hasConcept C180526460 @default.
- W2013504920 hasConcept C181199279 @default.
- W2013504920 hasConcept C185592680 @default.
- W2013504920 hasConcept C2778754761 @default.
- W2013504920 hasConcept C2780373914 @default.
- W2013504920 hasConcept C28406088 @default.
- W2013504920 hasConcept C519581460 @default.
- W2013504920 hasConcept C55493867 @default.
- W2013504920 hasConcept C71572567 @default.
- W2013504920 hasConcept C86803240 @default.
- W2013504920 hasConceptScore W2013504920C107872376 @default.
- W2013504920 hasConceptScore W2013504920C134018914 @default.
- W2013504920 hasConceptScore W2013504920C178790620 @default.
- W2013504920 hasConceptScore W2013504920C180526460 @default.
- W2013504920 hasConceptScore W2013504920C181199279 @default.
- W2013504920 hasConceptScore W2013504920C185592680 @default.
- W2013504920 hasConceptScore W2013504920C2778754761 @default.
- W2013504920 hasConceptScore W2013504920C2780373914 @default.
- W2013504920 hasConceptScore W2013504920C28406088 @default.
- W2013504920 hasConceptScore W2013504920C519581460 @default.
- W2013504920 hasConceptScore W2013504920C55493867 @default.
- W2013504920 hasConceptScore W2013504920C71572567 @default.
- W2013504920 hasConceptScore W2013504920C86803240 @default.
- W2013504920 hasIssue "8" @default.
- W2013504920 hasLocation W20135049201 @default.
- W2013504920 hasLocation W20135049202 @default.
- W2013504920 hasOpenAccess W2013504920 @default.
- W2013504920 hasPrimaryLocation W20135049201 @default.
- W2013504920 hasRelatedWork W1896982977 @default.
- W2013504920 hasRelatedWork W1970596670 @default.
- W2013504920 hasRelatedWork W1998362519 @default.
- W2013504920 hasRelatedWork W2013504920 @default.
- W2013504920 hasRelatedWork W2030770036 @default.
- W2013504920 hasRelatedWork W2079195928 @default.
- W2013504920 hasRelatedWork W2154136142 @default.
- W2013504920 hasRelatedWork W2160302014 @default.
- W2013504920 hasRelatedWork W2386408983 @default.
- W2013504920 hasRelatedWork W2565098243 @default.
- W2013504920 hasVolume "24" @default.
- W2013504920 isParatext "false" @default.
- W2013504920 isRetracted "false" @default.
- W2013504920 magId "2013504920" @default.
- W2013504920 workType "article" @default.