FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013507314> ?p ?o ?g. }

• W2013507314 endingPage "180" @default.
• W2013507314 startingPage "154" @default.
• W2013507314 abstract "There is considerable interest in the regulation of the extracellular compartment of the transmitter serotonin (5-hydroxytryptamine, 5-HT) in the midbrain raphe nuclei because it can control the activity of ascending serotonergic systems and the release of 5-HT in terminal areas of the forebrain. Several intrinsic and extrinsic factors of 5-HT neurons that regulate 5-HT release in the dorsal (DR) and median (MnR) raphe nucleus are reviewed in this article. Despite its high concentration in the extracellular space of the raphe nuclei, the origin of this pool of the transmitter remains to be determined. Regardless of its origin, is has been shown that the release of 5-HT in the rostral raphe nuclei is partly dependent on impulse flow and Ca2+ ions. The release in the DR and MnR is critically dependent on the activation of 5-HT autoreceptors in these nuclei. Yet, it appears that 5-HT autoreceptors do not tonically inhibit 5-HT release in the raphe nuclei but rather play a role as sensors that respond to an excess of the endogenous transmitter. Both DR and MnR are equally responsive to the reduction of 5-HT release elicited by the local perfusion of 5-HT1A receptor agonists. In contrast, the effects of selective 5-HT1B receptor agonists are more pronounced in the MnR than in the DR. However, the cellular localization of 5-HT1B receptors in the raphe nuclei remains to be established. Furthermore, endogenous noradrenaline and GABA tonically regulate the extracellular concentration of 5-HT although the degree of tonicity appears to depend upon the sleep/wake cycle and the behavioral state of the animal. Glutamate exerts a phasic facilitatory control over the release of 5-HT in the raphe nuclei through ionotropic glutamate receptors. Overall, it appears that the extracellular concentration of 5-HT in the DR and the MnR is tightly controlled by intrinsic serotonergic mechanisms as well as afferent connections." @default.
• W2013507314 created "2016-06-24" @default.
• W2013507314 creator A5022624402 @default.
• W2013507314 creator A5033849687 @default.
• W2013507314 creator A5045533329 @default.
• W2013507314 creator A5090507203 @default.
• W2013507314 date "2002-09-01" @default.
• W2013507314 modified "2023-10-16" @default.
• W2013507314 title "Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei" @default.
• W2013507314 cites W1492266111 @default.
• W2013507314 cites W1524233596 @default.
• W2013507314 cites W1530059721 @default.
• W2013507314 cites W1543276710 @default.
• W2013507314 cites W1555935568 @default.
• W2013507314 cites W1557005889 @default.
• W2013507314 cites W1569884359 @default.
• W2013507314 cites W1582206225 @default.
• W2013507314 cites W1591523569 @default.
• W2013507314 cites W1598392065 @default.
• W2013507314 cites W1618289512 @default.
• W2013507314 cites W1627229807 @default.
• W2013507314 cites W1631648021 @default.
• W2013507314 cites W1761987582 @default.
• W2013507314 cites W177190143 @default.
• W2013507314 cites W1810764863 @default.
• W2013507314 cites W1815738849 @default.
• W2013507314 cites W1828538530 @default.
• W2013507314 cites W1862144680 @default.
• W2013507314 cites W1865680049 @default.
• W2013507314 cites W1900806927 @default.
• W2013507314 cites W1912531269 @default.
• W2013507314 cites W1928975456 @default.
• W2013507314 cites W1963590565 @default.
• W2013507314 cites W1964838523 @default.
• W2013507314 cites W1965776451 @default.
• W2013507314 cites W1966076978 @default.
• W2013507314 cites W1966579748 @default.
• W2013507314 cites W1966701571 @default.
• W2013507314 cites W1966791005 @default.
• W2013507314 cites W1968934705 @default.
• W2013507314 cites W1970381031 @default.
• W2013507314 cites W1972252092 @default.
• W2013507314 cites W1972336848 @default.
• W2013507314 cites W1972816542 @default.
• W2013507314 cites W1974164080 @default.
• W2013507314 cites W1974624373 @default.
• W2013507314 cites W1974703596 @default.
• W2013507314 cites W1974869837 @default.
• W2013507314 cites W1974979359 @default.
• W2013507314 cites W1975275629 @default.
• W2013507314 cites W1975627286 @default.
• W2013507314 cites W1977886627 @default.
• W2013507314 cites W1978846422 @default.
• W2013507314 cites W1979019626 @default.
• W2013507314 cites W1981102082 @default.
• W2013507314 cites W1981271637 @default.
• W2013507314 cites W1981485683 @default.
• W2013507314 cites W1982060538 @default.
• W2013507314 cites W1983230599 @default.
• W2013507314 cites W1983303052 @default.
• W2013507314 cites W1984113489 @default.
• W2013507314 cites W1984345409 @default.
• W2013507314 cites W1984642996 @default.
• W2013507314 cites W1984868484 @default.
• W2013507314 cites W1986584374 @default.
• W2013507314 cites W1987299915 @default.
• W2013507314 cites W1987544940 @default.
• W2013507314 cites W1988939268 @default.
• W2013507314 cites W1989251239 @default.
• W2013507314 cites W1989309339 @default.
• W2013507314 cites W1989900998 @default.
• W2013507314 cites W1990189870 @default.
• W2013507314 cites W1990663975 @default.
• W2013507314 cites W1991398637 @default.
• W2013507314 cites W1993320854 @default.
• W2013507314 cites W1993665570 @default.
• W2013507314 cites W1994356583 @default.
• W2013507314 cites W1994514599 @default.
• W2013507314 cites W1994768518 @default.
• W2013507314 cites W1994894993 @default.
• W2013507314 cites W1995246557 @default.
• W2013507314 cites W1995365016 @default.
• W2013507314 cites W1995652573 @default.
• W2013507314 cites W1996345484 @default.
• W2013507314 cites W1997521545 @default.
• W2013507314 cites W1997716013 @default.
• W2013507314 cites W1997985883 @default.
• W2013507314 cites W1998088135 @default.
• W2013507314 cites W1998113639 @default.
• W2013507314 cites W1998310860 @default.
• W2013507314 cites W1998431387 @default.
• W2013507314 cites W1998846079 @default.
• W2013507314 cites W1999815661 @default.
• W2013507314 cites W2000532038 @default.
• W2013507314 cites W2001003931 @default.
• W2013507314 cites W2002227213 @default.
• W2013507314 cites W2003175705 @default.
• W2013507314 cites W2003329156 @default.

• next