FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013509971> ?p ?o ?g. }

• W2013509971 endingPage "602" @default.
• W2013509971 startingPage "593" @default.
• W2013509971 abstract "Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex with bacterial dihydrofolate reductase (DHFR). This conformation of TMP was achieved by linking the 4-amino function to the methylene group by one- and two-carbon bridges. A pyrrolo[2,3-d]pyrimidine, a dihydro analogue, and a tetrahydropyrido[2,3-d]pyrimidine were synthesized and tested as inhibitors of DHFR. One analogue showed activity equivalent to that of TMP against DHFR from three species of bacteria. An X-ray crystal structure of this inhibitor bound to Escherichia coli DHFR was determined to evaluate the structural consequences of the conformational restriction." @default.
• W2013509971 created "2016-06-24" @default.
• W2013509971 creator A5002792519 @default.
• W2013509971 creator A5036281662 @default.
• W2013509971 creator A5053621751 @default.
• W2013509971 creator A5062540538 @default.
• W2013509971 creator A5075376831 @default.
• W2013509971 creator A5083834001 @default.
• W2013509971 date "1996-04-01" @default.
• W2013509971 modified "2023-09-26" @default.
• W2013509971 title "Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim" @default.
• W2013509971 cites W1507156410 @default.
• W2013509971 cites W1575004573 @default.
• W2013509971 cites W1579562694 @default.
• W2013509971 cites W1841512813 @default.
• W2013509971 cites W1964877775 @default.
• W2013509971 cites W1968114952 @default.
• W2013509971 cites W1969222787 @default.
• W2013509971 cites W1973438035 @default.
• W2013509971 cites W2004014978 @default.
• W2013509971 cites W2012617907 @default.
• W2013509971 cites W2012758072 @default.
• W2013509971 cites W2046127559 @default.
• W2013509971 cites W2046467237 @default.
• W2013509971 cites W2046937483 @default.
• W2013509971 cites W2047145814 @default.
• W2013509971 cites W2059105573 @default.
• W2013509971 cites W2063716762 @default.
• W2013509971 cites W2065717154 @default.
• W2013509971 cites W2068556469 @default.
• W2013509971 cites W2079921984 @default.
• W2013509971 cites W2081487461 @default.
• W2013509971 cites W2131124255 @default.
• W2013509971 cites W2149795002 @default.
• W2013509971 cites W2158181144 @default.
• W2013509971 cites W2399865230 @default.
• W2013509971 cites W2401344372 @default.
• W2013509971 cites W2949847524 @default.
• W2013509971 cites W2950565045 @default.
• W2013509971 doi "https://doi.org/10.1016/0968-0896(96)00045-4" @default.
• W2013509971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8735847" @default.
• W2013509971 hasPublicationYear "1996" @default.
• W2013509971 type Work @default.
• W2013509971 sameAs 2013509971 @default.
• W2013509971 citedByCount "47" @default.
• W2013509971 countsByYear W20135099712012 @default.
• W2013509971 countsByYear W20135099712013 @default.
• W2013509971 countsByYear W20135099712014 @default.
• W2013509971 countsByYear W20135099712015 @default.
• W2013509971 countsByYear W20135099712016 @default.
• W2013509971 countsByYear W20135099712017 @default.
• W2013509971 countsByYear W20135099712018 @default.
• W2013509971 countsByYear W20135099712019 @default.
• W2013509971 countsByYear W20135099712020 @default.
• W2013509971 countsByYear W20135099712021 @default.
• W2013509971 crossrefType "journal-article" @default.
• W2013509971 hasAuthorship W2013509971A5002792519 @default.
• W2013509971 hasAuthorship W2013509971A5036281662 @default.
• W2013509971 hasAuthorship W2013509971A5053621751 @default.
• W2013509971 hasAuthorship W2013509971A5062540538 @default.
• W2013509971 hasAuthorship W2013509971A5075376831 @default.
• W2013509971 hasAuthorship W2013509971A5083834001 @default.
• W2013509971 hasConcept C104317684 @default.
• W2013509971 hasConcept C115624301 @default.
• W2013509971 hasConcept C178790620 @default.
• W2013509971 hasConcept C181199279 @default.
• W2013509971 hasConcept C185592680 @default.
• W2013509971 hasConcept C2777454769 @default.
• W2013509971 hasConcept C2778397455 @default.
• W2013509971 hasConcept C2779321679 @default.
• W2013509971 hasConcept C2780104969 @default.
• W2013509971 hasConcept C2780728791 @default.
• W2013509971 hasConcept C2781320022 @default.
• W2013509971 hasConcept C2781382166 @default.
• W2013509971 hasConcept C29730261 @default.
• W2013509971 hasConcept C3019249092 @default.
• W2013509971 hasConcept C501593827 @default.
• W2013509971 hasConcept C523546767 @default.
• W2013509971 hasConcept C54355233 @default.
• W2013509971 hasConcept C547475151 @default.
• W2013509971 hasConcept C55493867 @default.
• W2013509971 hasConcept C71240020 @default.
• W2013509971 hasConcept C86803240 @default.
• W2013509971 hasConceptScore W2013509971C104317684 @default.
• W2013509971 hasConceptScore W2013509971C115624301 @default.
• W2013509971 hasConceptScore W2013509971C178790620 @default.
• W2013509971 hasConceptScore W2013509971C181199279 @default.
• W2013509971 hasConceptScore W2013509971C185592680 @default.
• W2013509971 hasConceptScore W2013509971C2777454769 @default.
• W2013509971 hasConceptScore W2013509971C2778397455 @default.
• W2013509971 hasConceptScore W2013509971C2779321679 @default.
• W2013509971 hasConceptScore W2013509971C2780104969 @default.
• W2013509971 hasConceptScore W2013509971C2780728791 @default.
• W2013509971 hasConceptScore W2013509971C2781320022 @default.
• W2013509971 hasConceptScore W2013509971C2781382166 @default.
• W2013509971 hasConceptScore W2013509971C29730261 @default.
• W2013509971 hasConceptScore W2013509971C3019249092 @default.
• W2013509971 hasConceptScore W2013509971C501593827 @default.

• next