FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013511883> ?p ?o ?g. }

• W2013511883 endingPage "1214" @default.
• W2013511883 startingPage "1205" @default.
• W2013511883 abstract "Several variants of growth hormone (GH) are found in the retina and vitreous of the chick embryo, where they appear to act as cell survival factors, having neuroprotective effects on retinal ganglion cells (RGCs). Here, we investigate the molecular mechanisms of the anti-apoptotic effect of GH in cultured RGCs. GH treatment increased Akt phosphorylation in these cells, which is an anti-apoptotic event. Whereas unphosphorylated Akt was detected in both nucleus and cytoplasm of RGCs by immunocytochemistry, the phosphorylated form of Akt (Akt-phos) was located primarily in the cytoplasm of both normal and apoptotic cells, although levels were markedly lower in the latter. It was found that GH treatment of RGCs reduced Akt levels, while concomitantly raising Akt-phos levels, consistent with a role for Akt signaling pathways in GH neuroprotective action. This was substantiated using Wortmannin, which, like GH antiserum, inhibited Akt phosphorylation and initiated apoptosis. The addition of Wortmannin to RGC cultures simultaneously with GH significantly reduced the anti-apoptotic effect of GH. The induction of apoptosis by GH antiserum was clearly accompanied by an increase in caspase-3 activation and PARP-1 cleavage, both of which were significantly reduced in the presence of the broad spectrum caspase inhibitor, Q-VD-OPh, which itself had a dramatic neuroprotective effect on cultured RGCs. Calpain activation appeared to be a major caspase-independent pathway to PARP-1 cleavage and apoptosis in these cells. Calpain inhibitor III (MDL 28170) was able to reduce PARP-1 cleavage and abrogate the apoptogenic effect of GH antiserum. The results support the view that caspase and calpain inhibitors are major neuroprotective agents for RGCs, and that pathways that activate both caspases and calpains are important for the anti-apoptotic actions of GH in these cells." @default.
• W2013511883 created "2016-06-24" @default.
• W2013511883 creator A5044943603 @default.
• W2013511883 creator A5050803846 @default.
• W2013511883 creator A5058824765 @default.
• W2013511883 date "2006-11-01" @default.
• W2013511883 modified "2023-09-23" @default.
• W2013511883 title "Retinal ganglion cell survival in development: Mechanisms of retinal growth hormone action" @default.
• W2013511883 cites W1563169973 @default.
• W2013511883 cites W1593388227 @default.
• W2013511883 cites W171619253 @default.
• W2013511883 cites W1964420304 @default.
• W2013511883 cites W1974089466 @default.
• W2013511883 cites W1979041469 @default.
• W2013511883 cites W1991797136 @default.
• W2013511883 cites W1996397393 @default.
• W2013511883 cites W1998575108 @default.
• W2013511883 cites W2008186920 @default.
• W2013511883 cites W2008508452 @default.
• W2013511883 cites W2014091945 @default.
• W2013511883 cites W2019011834 @default.
• W2013511883 cites W2019547209 @default.
• W2013511883 cites W2022515102 @default.
• W2013511883 cites W2024306318 @default.
• W2013511883 cites W2027758997 @default.
• W2013511883 cites W2028613780 @default.
• W2013511883 cites W2028861052 @default.
• W2013511883 cites W2028869377 @default.
• W2013511883 cites W2029962300 @default.
• W2013511883 cites W2038520499 @default.
• W2013511883 cites W2042695033 @default.
• W2013511883 cites W2044858838 @default.
• W2013511883 cites W2046716965 @default.
• W2013511883 cites W2048243096 @default.
• W2013511883 cites W2049487230 @default.
• W2013511883 cites W2053105976 @default.
• W2013511883 cites W2060461238 @default.
• W2013511883 cites W2062455504 @default.
• W2013511883 cites W2071487260 @default.
• W2013511883 cites W2072913100 @default.
• W2013511883 cites W2074668040 @default.
• W2013511883 cites W2075218265 @default.
• W2013511883 cites W2077462719 @default.
• W2013511883 cites W2077482634 @default.
• W2013511883 cites W2077598293 @default.
• W2013511883 cites W2079091267 @default.
• W2013511883 cites W2082768140 @default.
• W2013511883 cites W2087473057 @default.
• W2013511883 cites W2088680428 @default.
• W2013511883 cites W2089202414 @default.
• W2013511883 cites W2089583564 @default.
• W2013511883 cites W2089834367 @default.
• W2013511883 cites W2090663596 @default.
• W2013511883 cites W2090795299 @default.
• W2013511883 cites W2091299313 @default.
• W2013511883 cites W2104715927 @default.
• W2013511883 cites W2120181693 @default.
• W2013511883 cites W2122087624 @default.
• W2013511883 cites W2130446433 @default.
• W2013511883 cites W2136565832 @default.
• W2013511883 cites W2143697364 @default.
• W2013511883 cites W2156495606 @default.
• W2013511883 cites W2168171339 @default.
• W2013511883 cites W2172159030 @default.
• W2013511883 cites W2184515547 @default.
• W2013511883 cites W2327050912 @default.
• W2013511883 cites W2331412123 @default.
• W2013511883 cites W2334742250 @default.
• W2013511883 cites W2343452072 @default.
• W2013511883 cites W2436039524 @default.
• W2013511883 cites W4245361947 @default.
• W2013511883 doi "https://doi.org/10.1016/j.exer.2006.06.009" @default.
• W2013511883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16893540" @default.
• W2013511883 hasPublicationYear "2006" @default.
• W2013511883 type Work @default.
• W2013511883 sameAs 2013511883 @default.
• W2013511883 citedByCount "44" @default.
• W2013511883 countsByYear W20135118832012 @default.
• W2013511883 countsByYear W20135118832013 @default.
• W2013511883 countsByYear W20135118832014 @default.
• W2013511883 countsByYear W20135118832015 @default.
• W2013511883 countsByYear W20135118832016 @default.
• W2013511883 countsByYear W20135118832017 @default.
• W2013511883 countsByYear W20135118832018 @default.
• W2013511883 countsByYear W20135118832019 @default.
• W2013511883 countsByYear W20135118832022 @default.
• W2013511883 crossrefType "journal-article" @default.
• W2013511883 hasAuthorship W2013511883A5044943603 @default.
• W2013511883 hasAuthorship W2013511883A5050803846 @default.
• W2013511883 hasAuthorship W2013511883A5058824765 @default.
• W2013511883 hasConcept C11960822 @default.
• W2013511883 hasConcept C126322002 @default.
• W2013511883 hasConcept C134018914 @default.
• W2013511883 hasConcept C169760540 @default.
• W2013511883 hasConcept C181199279 @default.
• W2013511883 hasConcept C190283241 @default.
• W2013511883 hasConcept C25498285 @default.
• W2013511883 hasConcept C2777093970 @default.

• next