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• W2013514511 abstract "Relationships among tenascin expression, DNA ploidy, and P-glycoprotein were examined in 81 primary human colon cancers and 61 metastatic lymph nodes. First, the DNA ploidy patterns of colon cancerous tissue surrounded (TN+) and not surrounded (TN−) by tenascin immunoreactivity were investigated. Then the expression of P-glycoprotein, one of two multidrug resistance gene products, was examined in TN+ and TN− colon cancer tissues by immunohistochemistry. Aneuploid DNA patterns were observed at high frequency in TN colon cancer tissues (37/61) and metastatic lymph nodes (44/52). In contrast, diploid DNA patterns were observed predominantly in TN+ colon cancer tissues (50/56). Although P-glycoprotein expression was observed in primary TN+ and TN− colon cancer (9/81), the level of P-glycoprotein expression was not correlated with DNA aneuploidy in TN−colon cancer tissues. Overall, reduced tenascin expression was correlated well with DNA aneuploidy, but no significant correlation was found between DNA aneuploidy and P-glycoprotein appearing when cancer cells become resistant to several anti-cancer drugs. Thus, tenascin may play an important role in preventing colon cancer cells from invading surrounding tissues." @default.
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• W2013514511 date "1993-07-01" @default.
• W2013514511 modified "2023-09-27" @default.
• W2013514511 title "Relationships among Tenascin Expression, DNA Ploidy Patterns, and Multidrug Resistance Gene Product (P-Glycoprotein) in Human Colon Carcinoma" @default.
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• W2013514511 doi "https://doi.org/10.1111/j.1349-7006.1993.tb02032.x" @default.
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