FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013514528> ?p ?o ?g. }

• W2013514528 endingPage "2188" @default.
• W2013514528 startingPage "2175" @default.
• W2013514528 abstract "The question whether general tetanus arises from the independent sum of multiple local tetani or results from the actions of the transynaptic tetanus neurotoxin (TeNT) in higher brain centres remains unresolved. Despite the blood-borne dissemination of TeNT from an infected wound, the access to the central nervous system is probably prevented by the blood-brain barrier. However, several long-term sequelae (e.g. autonomic dysfunction, seizures, myoclonus, and sleep disturbances) present after the subsidence of muscle spasms might be indicative of central actions that occur farther away from lower motoneurons. Subsequently, the obvious entry route is the peripheral neurons followed by the transynaptic passage to the brain. We aimed at describing the pathophysiological correlates of TeNT translocation using the oculomotor system as a comprehensive model of cell connectivity and neuronal firing properties. In this study, we report that injection of TeNT into the medial rectus muscle of one eye resulted in bilateral gaze palsy attributed to firing alterations found in the contralaterally projecting abducens internuclear neurons. Functional alterations in the abducens-to-oculomotor internuclear pathway resembled in part the classically described TeNT disinhibition. We confirmed the transynaptic targeted action of TeNT by analysing vesicle-associated membrane protein2 (VAMP2) immunoreactivity (the SNARE protein cleaved by TeNT). VAMP2 immunoreactivity decreased by 94.4% in the oculomotor nucleus (the first synaptic relay) and by 62.1% presynaptic to abducens neurons (the second synaptic relay). These results are the first demonstration of physiological changes in chains of connected neurons that are best explained by the transynaptic action of TeNT on premotor neurons as shown with VAMP2 immunoreactivity which serves as an indicator of TeNT activity." @default.
• W2013514528 created "2016-06-24" @default.
• W2013514528 creator A5003096476 @default.
• W2013514528 creator A5011496732 @default.
• W2013514528 creator A5028956737 @default.
• W2013514528 creator A5089429404 @default.
• W2013514528 creator A5090546937 @default.
• W2013514528 date "2005-06-29" @default.
• W2013514528 modified "2023-09-25" @default.
• W2013514528 title "Transynaptic effects of tetanus neurotoxin in the oculomotor system" @default.
• W2013514528 cites W1870620040 @default.
• W2013514528 cites W1917634662 @default.
• W2013514528 cites W1938184900 @default.
• W2013514528 cites W1974923318 @default.
• W2013514528 cites W1975698062 @default.
• W2013514528 cites W1975773005 @default.
• W2013514528 cites W1975939184 @default.
• W2013514528 cites W1980419833 @default.
• W2013514528 cites W1982162401 @default.
• W2013514528 cites W1983449473 @default.
• W2013514528 cites W1993133423 @default.
• W2013514528 cites W1994228114 @default.
• W2013514528 cites W2000367301 @default.
• W2013514528 cites W2005796985 @default.
• W2013514528 cites W2009780379 @default.
• W2013514528 cites W2010258335 @default.
• W2013514528 cites W2015771062 @default.
• W2013514528 cites W2024013639 @default.
• W2013514528 cites W2032653215 @default.
• W2013514528 cites W2032922588 @default.
• W2013514528 cites W2033993952 @default.
• W2013514528 cites W2036560581 @default.
• W2013514528 cites W2040344370 @default.
• W2013514528 cites W2043735007 @default.
• W2013514528 cites W2055822860 @default.
• W2013514528 cites W2058327767 @default.
• W2013514528 cites W2058580982 @default.
• W2013514528 cites W2060191631 @default.
• W2013514528 cites W2064629267 @default.
• W2013514528 cites W2065255454 @default.
• W2013514528 cites W2065584726 @default.
• W2013514528 cites W2074183622 @default.
• W2013514528 cites W2074872869 @default.
• W2013514528 cites W2076140025 @default.
• W2013514528 cites W2078233516 @default.
• W2013514528 cites W2079426657 @default.
• W2013514528 cites W2081042613 @default.
• W2013514528 cites W2083867490 @default.
• W2013514528 cites W2084440722 @default.
• W2013514528 cites W2085707380 @default.
• W2013514528 cites W2088013041 @default.
• W2013514528 cites W2092524511 @default.
• W2013514528 cites W2104786894 @default.
• W2013514528 cites W2122977798 @default.
• W2013514528 cites W2127549776 @default.
• W2013514528 cites W2146721301 @default.
• W2013514528 cites W2147252877 @default.
• W2013514528 cites W2205269180 @default.
• W2013514528 cites W2896314762 @default.
• W2013514528 cites W4251905562 @default.
• W2013514528 doi "https://doi.org/10.1093/brain/awh580" @default.
• W2013514528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15987757" @default.
• W2013514528 hasPublicationYear "2005" @default.
• W2013514528 type Work @default.
• W2013514528 sameAs 2013514528 @default.
• W2013514528 citedByCount "20" @default.
• W2013514528 countsByYear W20135145282013 @default.
• W2013514528 countsByYear W20135145282014 @default.
• W2013514528 countsByYear W20135145282016 @default.
• W2013514528 countsByYear W20135145282017 @default.
• W2013514528 countsByYear W20135145282018 @default.
• W2013514528 countsByYear W20135145282021 @default.
• W2013514528 countsByYear W20135145282023 @default.
• W2013514528 crossrefType "journal-article" @default.
• W2013514528 hasAuthorship W2013514528A5003096476 @default.
• W2013514528 hasAuthorship W2013514528A5011496732 @default.
• W2013514528 hasAuthorship W2013514528A5028956737 @default.
• W2013514528 hasAuthorship W2013514528A5089429404 @default.
• W2013514528 hasAuthorship W2013514528A5090546937 @default.
• W2013514528 hasBestOaLocation W20135145281 @default.
• W2013514528 hasConcept C134018914 @default.
• W2013514528 hasConcept C153050134 @default.
• W2013514528 hasConcept C15744967 @default.
• W2013514528 hasConcept C169760540 @default.
• W2013514528 hasConcept C2779845715 @default.
• W2013514528 hasConcept C2780358027 @default.
• W2013514528 hasConcept C86803240 @default.
• W2013514528 hasConceptScore W2013514528C134018914 @default.
• W2013514528 hasConceptScore W2013514528C153050134 @default.
• W2013514528 hasConceptScore W2013514528C15744967 @default.
• W2013514528 hasConceptScore W2013514528C169760540 @default.
• W2013514528 hasConceptScore W2013514528C2779845715 @default.
• W2013514528 hasConceptScore W2013514528C2780358027 @default.
• W2013514528 hasConceptScore W2013514528C86803240 @default.
• W2013514528 hasIssue "9" @default.
• W2013514528 hasLocation W20135145281 @default.
• W2013514528 hasLocation W20135145282 @default.
• W2013514528 hasLocation W20135145283 @default.

• next