Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013552978> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2013552978 endingPage "214" @default.
- W2013552978 startingPage "209" @default.
- W2013552978 abstract "Histogranin (HN) was first isolated from bovine adrenal medulla and shown to be a pentadecapeptide displaying N-methyl-D-aspartate (NMDA) receptor antagonist activity. To determine the active pharmacophore of HN, fragments of the peptide were synthesized and their structure–activity relationships studied by measuring their ability to displace the binding of [ 125 I][Ser 1 ]HN to rat brain membrane preparations and to block NMDA-induced convulsions in mice. In the binding assay, only the full length peptide HN and HN(1–10) displayed a high affinity (K i of 72 and 162 nM, respectively). All other tested fragments with deletions at the N- and (or) C-terminals of the molecule showed large (16- to 2500-fold) decreases in potency. The least active peptide fragment tested was HN(6–10) (K i of 164 μM). In vivo, HN and HN(2–15) (100 nmol; i.c.v.) produced 94 and 40% protection against NMDA-induced convulsions in mice, respectively. None of the other peptide fragments displayed significant anticonvulsant activity. The protective activity of HN (60 and 100 nmol) was markedly antagonized by coadministration of HN(1–10) (100 nmol). The results indicate that the in vivo anti-NMDA and in vitro binding activities of HN and related peptides, with the exception of HN(1–10), depend upon the integrity of the molecule. On the other hand, the high affinity of HN(1–10) for HN binding sites correlates well with its antagonist effects towards the activity of the parent peptide.Key words: histogranin, peptide receptor, N-methyl-D-aspartate receptor, anticonvulsant." @default.
- W2013552978 created "2016-06-24" @default.
- W2013552978 creator A5006331157 @default.
- W2013552978 creator A5015273914 @default.
- W2013552978 creator A5059911011 @default.
- W2013552978 date "1995-02-01" @default.
- W2013552978 modified "2023-09-27" @default.
- W2013552978 title "Synthesis and biological activity of histogranin and related peptides" @default.
- W2013552978 cites W1490334811 @default.
- W2013552978 cites W1992998610 @default.
- W2013552978 cites W1993916865 @default.
- W2013552978 cites W1998347917 @default.
- W2013552978 cites W2018247447 @default.
- W2013552978 cites W2025801062 @default.
- W2013552978 cites W2033785962 @default.
- W2013552978 cites W2045280684 @default.
- W2013552978 cites W2048706245 @default.
- W2013552978 cites W2070801110 @default.
- W2013552978 cites W2071529758 @default.
- W2013552978 cites W2074631079 @default.
- W2013552978 cites W2086928765 @default.
- W2013552978 cites W2093734160 @default.
- W2013552978 cites W2100040827 @default.
- W2013552978 cites W2137926707 @default.
- W2013552978 cites W2147737086 @default.
- W2013552978 cites W2167465587 @default.
- W2013552978 cites W2245167357 @default.
- W2013552978 cites W2320556745 @default.
- W2013552978 doi "https://doi.org/10.1139/y95-030" @default.
- W2013552978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7621358" @default.
- W2013552978 hasPublicationYear "1995" @default.
- W2013552978 type Work @default.
- W2013552978 sameAs 2013552978 @default.
- W2013552978 citedByCount "11" @default.
- W2013552978 countsByYear W20135529782016 @default.
- W2013552978 countsByYear W20135529782017 @default.
- W2013552978 countsByYear W20135529782021 @default.
- W2013552978 countsByYear W20135529782022 @default.
- W2013552978 crossrefType "journal-article" @default.
- W2013552978 hasAuthorship W2013552978A5006331157 @default.
- W2013552978 hasAuthorship W2013552978A5015273914 @default.
- W2013552978 hasAuthorship W2013552978A5059911011 @default.
- W2013552978 hasConcept C116073593 @default.
- W2013552978 hasConcept C150903083 @default.
- W2013552978 hasConcept C153911025 @default.
- W2013552978 hasConcept C170493617 @default.
- W2013552978 hasConcept C185592680 @default.
- W2013552978 hasConcept C202751555 @default.
- W2013552978 hasConcept C207001950 @default.
- W2013552978 hasConcept C2776885963 @default.
- W2013552978 hasConcept C2779281246 @default.
- W2013552978 hasConcept C55493867 @default.
- W2013552978 hasConcept C56173144 @default.
- W2013552978 hasConcept C67018056 @default.
- W2013552978 hasConcept C71240020 @default.
- W2013552978 hasConcept C86803240 @default.
- W2013552978 hasConceptScore W2013552978C116073593 @default.
- W2013552978 hasConceptScore W2013552978C150903083 @default.
- W2013552978 hasConceptScore W2013552978C153911025 @default.
- W2013552978 hasConceptScore W2013552978C170493617 @default.
- W2013552978 hasConceptScore W2013552978C185592680 @default.
- W2013552978 hasConceptScore W2013552978C202751555 @default.
- W2013552978 hasConceptScore W2013552978C207001950 @default.
- W2013552978 hasConceptScore W2013552978C2776885963 @default.
- W2013552978 hasConceptScore W2013552978C2779281246 @default.
- W2013552978 hasConceptScore W2013552978C55493867 @default.
- W2013552978 hasConceptScore W2013552978C56173144 @default.
- W2013552978 hasConceptScore W2013552978C67018056 @default.
- W2013552978 hasConceptScore W2013552978C71240020 @default.
- W2013552978 hasConceptScore W2013552978C86803240 @default.
- W2013552978 hasIssue "2" @default.
- W2013552978 hasLocation W20135529781 @default.
- W2013552978 hasLocation W20135529782 @default.
- W2013552978 hasOpenAccess W2013552978 @default.
- W2013552978 hasPrimaryLocation W20135529781 @default.
- W2013552978 hasRelatedWork W1981071014 @default.
- W2013552978 hasRelatedWork W2000975824 @default.
- W2013552978 hasRelatedWork W2043576708 @default.
- W2013552978 hasRelatedWork W2046594262 @default.
- W2013552978 hasRelatedWork W2062859678 @default.
- W2013552978 hasRelatedWork W2076959752 @default.
- W2013552978 hasRelatedWork W2091740796 @default.
- W2013552978 hasRelatedWork W2276717060 @default.
- W2013552978 hasRelatedWork W2949732004 @default.
- W2013552978 hasRelatedWork W2953307709 @default.
- W2013552978 hasVolume "73" @default.
- W2013552978 isParatext "false" @default.
- W2013552978 isRetracted "false" @default.
- W2013552978 magId "2013552978" @default.
- W2013552978 workType "article" @default.