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- W2013553312 abstract "An investigation has been made of the effects of experimentally induced diabetes and subsequent insulin treatment on the ultrastructure of the rat hepatocyte. The distribution of liver ribosomes between the free and membrane-bound populations and the activities of these fractions in cell-free protein synthesis have been compared in the normal and diabetic states. Mild diabetes results in extensive disruption of the rough endoplasmic reticulum and leads to the appearance of large lysosomes. Chronic insulin treatment restores the ultrastructure of the liver to that seen in normal animals. The changes in organization of the rough endoplasmic reticulum induced by diabetes are accompanied by a small increase in the proportion of the free ribosomes in the total population without any significant change in total RNA content per gram of liver. The ability of membrane-bound ribosomes to incorporate a radioactive amino acid into protein in vitro is 2–3 times higher than that of free ribosomes (per unit RNA) when measured by incubation and subsequent fractionation of post-mitochondrial supernatants. Diabetes impairs the activity of both populations by 20–30%. These results are considered in relation to the effects of diabetes and insulin treatment on rates of protein synthesis in the liver in vivo." @default.
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- W2013553312 date "1974-07-01" @default.
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- W2013553312 title "Effect of diabetes on the ultrastructure of the hepatocyte and on the distribution and activity of ribosomes in the free and membrane-bound populations" @default.
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- W2013553312 doi "https://doi.org/10.1016/0005-2787(74)90054-9" @default.
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