Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013557046> ?p ?o ?g. }
- W2013557046 endingPage "84" @default.
- W2013557046 startingPage "73" @default.
- W2013557046 abstract "Infertility represents a major clinical problem and 50% of cases are attributable to the male partner. Testicular function is temperature dependent, and in both man and mouse the position of the testes in the scrotum ensures that they are kept at between 2 and 8 degrees C below core body temperature. We used a mouse model to investigate the impact of a single, transient, mild, scrotal heat stress (38, 40 or 42 degrees C for 30 min) on testicular function, sperm DNA integrity and embryo survival. We detected temperature-dependent changes in testicular architecture, number of apoptotic cells and a significant reduction in testis weight 7 and 14 days after heat stress at 42 degrees C. We report for the first time that DNA strand breaks (gamma-H2AX-positive foci) were present in spermatocytes recovered from testes subjected to 40 or 42 degrees C. Fertility of heat-stressed males was tested 23-28 d after treatment (sperm at this time would have been spermatocytes at time of heating). Paternal heat stress at 42 degrees C resulted in reduced pregnancy rate, placental weight and litter size; pregnancies from the 40 degrees C group had increased resorptions at e14.5. Abnormalities in embryonic development were detected at e3.5 and in vitro fertilisation with sperm recovered 16 h or 23 d after scrotal stress at 42 degrees C revealed a block in development between the 4-cell and blastocyst stages. This study has provided evidence of temperature-dependent effects on germ cell DNA integrity and highlighted the importance of an intact paternal genome for normal embryo development." @default.
- W2013557046 created "2016-06-24" @default.
- W2013557046 creator A5006086053 @default.
- W2013557046 creator A5030863406 @default.
- W2013557046 creator A5038808662 @default.
- W2013557046 creator A5046963403 @default.
- W2013557046 date "2008-07-01" @default.
- W2013557046 modified "2023-10-01" @default.
- W2013557046 title "A single, mild, transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in mice" @default.
- W2013557046 cites W1463597244 @default.
- W2013557046 cites W1584624964 @default.
- W2013557046 cites W1906622425 @default.
- W2013557046 cites W1957763880 @default.
- W2013557046 cites W1966972829 @default.
- W2013557046 cites W1978373639 @default.
- W2013557046 cites W1982100349 @default.
- W2013557046 cites W1983884639 @default.
- W2013557046 cites W1985775217 @default.
- W2013557046 cites W1988440950 @default.
- W2013557046 cites W1990205404 @default.
- W2013557046 cites W1991633473 @default.
- W2013557046 cites W1992324036 @default.
- W2013557046 cites W1992537746 @default.
- W2013557046 cites W1994388349 @default.
- W2013557046 cites W1997444723 @default.
- W2013557046 cites W2001000016 @default.
- W2013557046 cites W2004995471 @default.
- W2013557046 cites W2005621683 @default.
- W2013557046 cites W2005942028 @default.
- W2013557046 cites W2009757749 @default.
- W2013557046 cites W2010819904 @default.
- W2013557046 cites W2014902921 @default.
- W2013557046 cites W2016552156 @default.
- W2013557046 cites W2019405732 @default.
- W2013557046 cites W2021969394 @default.
- W2013557046 cites W2026246636 @default.
- W2013557046 cites W2028114722 @default.
- W2013557046 cites W2053941291 @default.
- W2013557046 cites W2054280836 @default.
- W2013557046 cites W2060706539 @default.
- W2013557046 cites W2060806085 @default.
- W2013557046 cites W2062263569 @default.
- W2013557046 cites W2069890053 @default.
- W2013557046 cites W2075805514 @default.
- W2013557046 cites W2085399046 @default.
- W2013557046 cites W2086397190 @default.
- W2013557046 cites W2090310697 @default.
- W2013557046 cites W2091044340 @default.
- W2013557046 cites W2096374348 @default.
- W2013557046 cites W2097420884 @default.
- W2013557046 cites W2097711048 @default.
- W2013557046 cites W2097729713 @default.
- W2013557046 cites W2098262110 @default.
- W2013557046 cites W2099315470 @default.
- W2013557046 cites W2105719125 @default.
- W2013557046 cites W2105818850 @default.
- W2013557046 cites W2109269254 @default.
- W2013557046 cites W2115967293 @default.
- W2013557046 cites W2128843448 @default.
- W2013557046 cites W2130558170 @default.
- W2013557046 cites W2133846991 @default.
- W2013557046 cites W2134726260 @default.
- W2013557046 cites W2142901670 @default.
- W2013557046 cites W2147672884 @default.
- W2013557046 cites W2149224534 @default.
- W2013557046 cites W2160413910 @default.
- W2013557046 cites W2161506037 @default.
- W2013557046 cites W2168279270 @default.
- W2013557046 cites W2169721147 @default.
- W2013557046 cites W2282672234 @default.
- W2013557046 cites W4229540838 @default.
- W2013557046 cites W4243745865 @default.
- W2013557046 cites W4251408749 @default.
- W2013557046 cites W96412684 @default.
- W2013557046 doi "https://doi.org/10.1530/rep-08-0036" @default.
- W2013557046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18390691" @default.
- W2013557046 hasPublicationYear "2008" @default.
- W2013557046 type Work @default.
- W2013557046 sameAs 2013557046 @default.
- W2013557046 citedByCount "221" @default.
- W2013557046 countsByYear W20135570462012 @default.
- W2013557046 countsByYear W20135570462013 @default.
- W2013557046 countsByYear W20135570462014 @default.
- W2013557046 countsByYear W20135570462015 @default.
- W2013557046 countsByYear W20135570462016 @default.
- W2013557046 countsByYear W20135570462017 @default.
- W2013557046 countsByYear W20135570462018 @default.
- W2013557046 countsByYear W20135570462019 @default.
- W2013557046 countsByYear W20135570462020 @default.
- W2013557046 countsByYear W20135570462021 @default.
- W2013557046 countsByYear W20135570462022 @default.
- W2013557046 countsByYear W20135570462023 @default.
- W2013557046 crossrefType "journal-article" @default.
- W2013557046 hasAuthorship W2013557046A5006086053 @default.
- W2013557046 hasAuthorship W2013557046A5030863406 @default.
- W2013557046 hasAuthorship W2013557046A5038808662 @default.
- W2013557046 hasAuthorship W2013557046A5046963403 @default.
- W2013557046 hasBestOaLocation W20135570461 @default.