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• W2013557655 abstract "L1210 cells treated with l-buthionine-(S/R)-sulfoximine (BSO) had glutathione (GSH) and non-protein thiol levels only 15% that of control. These GSH-depleted cells grew as well as the control L1210 cells and there was no decrease in ribonucleotide reductase activity in situ as measured by the conversion of [14C]cytidine to deoxytidine nucleotides and incorporation into DNA. Further, when these BSO-stressed cells were treated with hydroxyurea or IMPY, there was no potentiation of the inhibition caused by hydroxyurea or IMPY alone. These data indicate that the glutathione/glutaredoxin system of ribonucleotide reductase is not the sole carrier of reducing equivalents from NADPH for the reduction of the 2′-position of the corresponding ribonucleoside 5′-diphosphate; and that glutathione is not critical in regenerating the tyrosyl free-radical on the M2 subunit which is destroyed by the hydroxyurea or 2,3-dihydro-1H-pyrazolo-[2,3-a]imidazole (IMPY) treatment." @default.
• W2013557655 created "2016-06-24" @default.
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• W2013557655 date "1988-06-01" @default.
• W2013557655 modified "2023-10-16" @default.
• W2013557655 title "Ribonucleotide reductase activity and growth of glutathione-depleted mouse leukemia L1210 cells in vitro" @default.
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• W2013557655 doi "https://doi.org/10.1016/0304-3835(88)90084-5" @default.
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