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- W2013560147 abstract "Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M–S, 1–7) and seven known compounds (8–14), were isolated from the aerial parts of Isodon sculponeatus. Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 μM, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 μM." @default.
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- W2013560147 date "2013-11-12" @default.
- W2013560147 modified "2023-10-16" @default.
- W2013560147 title "Enmein-type 6,7-<i>seco-ent</i>-Kauranoids from <i>Isodon sculponeatus</i>" @default.
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- W2013560147 doi "https://doi.org/10.1021/np400669t" @default.
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