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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013560358> ?p ?o ?g. }

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• W2013560358 abstract "The 1H-imidazoles 7a-e were synthesized and tested for biological activity in vitro. The results pointed to a clear structure-activity relationship. The introduction of an ethyl chain at C5 of the 1,2,4-tris(4-hydroxyphenyl)-1H-imidazole 7a caused hormonal activity in estrogen receptor positive MCF-7-2a cells. An o-chlorine substituent in the phenolic rings at C2 and C4 as realized in 7b and 7c increased the antiproliferative effects against human breast cancer cell lines MCF-7 and MDA-MB 231. Additionally, both compounds showed strong inhibitory effects on cyclooxygenase enzymes. Therefore, a mode of action including the interference in the arachidonic acid cascade might be possible." @default.
• W2013560358 created "2016-06-24" @default.
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• W2013560358 date "2005-09-14" @default.
• W2013560358 modified "2023-10-10" @default.
• W2013560358 title "Synthesis and Pharmacological Evaluation of 1<i>H</i>-Imidazoles as Ligands for the Estrogen Receptor and Cytotoxic Inhibitors of the Cyclooxygenase" @default.
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• W2013560358 doi "https://doi.org/10.1021/jm050190u" @default.
• W2013560358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16190777" @default.
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