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- W2013560946 abstract "Background Immunosuppressants must be guided by therapeutic drug monitoring (TDM) to prevent rejection. Understanding and prevention of blood level variability is essential. Purpose To evaluate TDM practice and factors associated with stabilisation. Materials and methods Retrospective study of paediatric patients with liver (LT; since 2007) or kidney transplant (KT; since 2002) in two university hospitals. First-month % of tacrolimus (FK) and ciclosporin (CyA) therapeutic trough levels (FK: LT 10-15 ng/mL; KT 8-12 ng/mL / CyA KT 250-350 mcg/L). 30-day survival analysis (median survival in days (d) (CI 95%)) of stabilisation (discharge from intensive care or hospital / 3 consecutive therapeutic levels) and univariate analysis of associated factors in LT with stabilisation (log-rank test). Results 46 patients included: 27 LT, 19 KT; mean age: 2.8 ±4.0 vs. 11.9 ±6.2 years. 100% of LT patients received FK; KT: 53% FK, 47% CyA. Only 32% (LT) and 41% (KT) of FK levels, and 22% (KT) of CyA levels were in the range. Discharge from intensive care and hospital occurred significantly later for LT (8d (6;12) versus 3 d (3;5) / 28 d (25; not available) versus 11.5 d (10;15) (p Conclusions Variability of immunosuppressant trough levels was high in the first month after liver transplantation and in kidney patients receiving ciclosporin. Factors associated with earlier stabilisation have to be confirmed in a larger study." @default.
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- W2013560946 date "2012-03-12" @default.
- W2013560946 modified "2023-10-07" @default.
- W2013560946 title "TDM and stabilisation of paediatric patients in liver and kidney transplantation" @default.
- W2013560946 doi "https://doi.org/10.1136/ejhpharm-2012-000074.287" @default.
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