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• W2013567689 abstract "Purified colony stimulating factor (CSF-1) stimulates the Na+, K+-ATPase activity of murine bone marrow-derived macrophages (BMM) and resident peritoneal macrophages (RPM) measured as ouabain-sensitive 86Rb+ uptake. Similar concentrations of CSF-1 stimulate the Na+, K+-ATPase activity and DNA synthesis in BMM whilst ouabain, a specific inhibitor of the Na+, K+-ATPase, also inhibits this CSF-1-mediated DNA synthesis. Other purified hemopoietic growth factors, granulocyte-macrophage CSF (GM-CSF) and interleukin-3 (IL-3), and the tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), even though differing in their mitogenic capabilities, are also stimulators of the Na+,K+-ATPase activity in BMM and RPM. The non-mitogenic agents, lipopolysaccharide (LPS) and Concanavalin A (Con A), are also active. CSF-1 stimulation of the Na+,K+-ATPase was shown to be dependent on elevation of intracellular Na+ via an amiloride sensitive Na+-channel, most likely representing Na+/H+ exchange activity. Such stimulation of Na+,K+-ATPase activity via activation of the Na+/H+ exchange appears to be a necessary but insufficient early macrophage response for subsequent DNA synthesis." @default.
• W2013567689 created "2016-06-24" @default.
• W2013567689 creator A5026903949 @default.
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• W2013567689 date "1988-01-01" @default.
• W2013567689 modified "2023-10-18" @default.
• W2013567689 title "Activation and proliferation signals in murine macrophages: Stimulation of Na+, K+-ATPase activity by hemopoietic growth factors and other agents" @default.
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• W2013567689 doi "https://doi.org/10.1002/jcp.1041340103" @default.
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