FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013573314> ?p ?o ?g. }

• W2013573314 endingPage "121" @default.
• W2013573314 startingPage "113" @default.
• W2013573314 abstract "Methamphetamine profoundly increases brain monoamines and is a widely abused psychostimulant. The effects of methamphetamine self-administration on neuron function are not known for the nucleus accumbens, a brain region involved in addictive behaviors, including drug-seeking. One therapeutic target showing preclinical promise at attenuating psychostimulant-seeking is 5-HT2C receptors; however, the effects of 5-HT2C receptor ligands on neuronal physiology are unclear. 5-HT2C receptor agonism decreases psychostimulant-mediated behaviors, and the putative 5-HT2C receptor inverse agonist, SB 206553, attenuates methamphetamine-seeking in rats. To ascertain the effects of methamphetamine, and 5-HT2C receptor inverse agonism and agonism, on neuronal function in the nucleus accumbens, we evaluated methamphetamine, SB 206553, and the 5-HT2C receptor agonist and Ro 60-0175, on neuronal excitability within the accumbens shell subregion using whole-cell current-clamp recordings in forebrain slices ex vivo. We reveal that methamphetamine self-administration decreased generation of evoked action potentials. In contrast, SB 206553 and Ro 60-0175 increased evoked spiking, effects that were prevented by the 5-HT2C receptor antagonist, SB 242084. We also assessed signaling mechanisms engaged by 5-HT2C receptors, and determined that accumbal 5-HT2C receptors stimulated Gq, but not Gi/o. These findings demonstrate that methamphetamine-induced decreases in excitability of neurons within the nucleus accumbens shell were abrogated by both 5-HT2C inverse agonism and agonism, and this effect likely involved activation of Gq-mediated signaling pathways." @default.
• W2013573314 created "2016-06-24" @default.
• W2013573314 creator A5011308742 @default.
• W2013573314 creator A5022375777 @default.
• W2013573314 creator A5044982284 @default.
• W2013573314 creator A5060334059 @default.
• W2013573314 creator A5085381524 @default.
• W2013573314 date "2015-02-01" @default.
• W2013573314 modified "2023-10-16" @default.
• W2013573314 title "Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism" @default.
• W2013573314 cites W1545745805 @default.
• W2013573314 cites W1550537001 @default.
• W2013573314 cites W1567696719 @default.
• W2013573314 cites W1598372418 @default.
• W2013573314 cites W1623913572 @default.
• W2013573314 cites W1695992398 @default.
• W2013573314 cites W1767247242 @default.
• W2013573314 cites W1933148766 @default.
• W2013573314 cites W1962727914 @default.
• W2013573314 cites W1972047614 @default.
• W2013573314 cites W1974183957 @default.
• W2013573314 cites W1975055078 @default.
• W2013573314 cites W1979575761 @default.
• W2013573314 cites W1980890656 @default.
• W2013573314 cites W1981264895 @default.
• W2013573314 cites W1983976011 @default.
• W2013573314 cites W1989715374 @default.
• W2013573314 cites W1989880151 @default.
• W2013573314 cites W1994747541 @default.
• W2013573314 cites W1994792053 @default.
• W2013573314 cites W1995566079 @default.
• W2013573314 cites W1996078493 @default.
• W2013573314 cites W1997550984 @default.
• W2013573314 cites W1998774082 @default.
• W2013573314 cites W2001302863 @default.
• W2013573314 cites W2001311556 @default.
• W2013573314 cites W2006882116 @default.
• W2013573314 cites W2010320160 @default.
• W2013573314 cites W2011267339 @default.
• W2013573314 cites W2014415095 @default.
• W2013573314 cites W2014989557 @default.
• W2013573314 cites W2018046822 @default.
• W2013573314 cites W2023214282 @default.
• W2013573314 cites W2027272303 @default.
• W2013573314 cites W2030600537 @default.
• W2013573314 cites W2033160727 @default.
• W2013573314 cites W2033519360 @default.
• W2013573314 cites W2037836204 @default.
• W2013573314 cites W2041018266 @default.
• W2013573314 cites W2049143190 @default.
• W2013573314 cites W2053748471 @default.
• W2013573314 cites W2057855503 @default.
• W2013573314 cites W2059477617 @default.
• W2013573314 cites W2064872795 @default.
• W2013573314 cites W2067657666 @default.
• W2013573314 cites W2070002407 @default.
• W2013573314 cites W2070264479 @default.
• W2013573314 cites W2070280529 @default.
• W2013573314 cites W2073346596 @default.
• W2013573314 cites W2073595900 @default.
• W2013573314 cites W2075901584 @default.
• W2013573314 cites W2076432636 @default.
• W2013573314 cites W2077723441 @default.
• W2013573314 cites W2081026141 @default.
• W2013573314 cites W2085654164 @default.
• W2013573314 cites W2087251224 @default.
• W2013573314 cites W2089210700 @default.
• W2013573314 cites W2094919279 @default.
• W2013573314 cites W2102355057 @default.
• W2013573314 cites W2102864812 @default.
• W2013573314 cites W2104446705 @default.
• W2013573314 cites W2109518858 @default.
• W2013573314 cites W2110779613 @default.
• W2013573314 cites W2131131065 @default.
• W2013573314 cites W2132622783 @default.
• W2013573314 cites W2145000368 @default.
• W2013573314 cites W2155768247 @default.
• W2013573314 cites W2164339448 @default.
• W2013573314 cites W2165018968 @default.
• W2013573314 cites W2165194242 @default.
• W2013573314 cites W2166103925 @default.
• W2013573314 cites W2169765156 @default.
• W2013573314 cites W4232534952 @default.
• W2013573314 doi "https://doi.org/10.1016/j.neuropharm.2014.09.001" @default.
• W2013573314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4321813" @default.
• W2013573314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25229719" @default.
• W2013573314 hasPublicationYear "2015" @default.
• W2013573314 type Work @default.
• W2013573314 sameAs 2013573314 @default.
• W2013573314 citedByCount "24" @default.
• W2013573314 countsByYear W20135733142015 @default.
• W2013573314 countsByYear W20135733142016 @default.
• W2013573314 countsByYear W20135733142017 @default.
• W2013573314 countsByYear W20135733142018 @default.
• W2013573314 countsByYear W20135733142019 @default.
• W2013573314 countsByYear W20135733142020 @default.
• W2013573314 countsByYear W20135733142021 @default.
• W2013573314 countsByYear W20135733142022 @default.

• next