FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013573722> ?p ?o ?g. }

• W2013573722 endingPage "180" @default.
• W2013573722 startingPage "173" @default.
• W2013573722 abstract "We have previously reported that among the other death proteins, hepatic secretory phospholipase A₂ (sPLA₂) is a leading mediator of progression of liver injury initiated by CCl₄ in rats. The aim of our present study was to test the hypothesis that increased hepatic sPLA₂ released after acetaminophen (APAP) challenge mediates progression of liver injury in wild type (WT) and COX-2 knockout (KO) mice. COX-2 WT and KO mice were administered a normally non lethal dose (400 mg/kg) of acetaminophen. The COX-2 KO mice suffered 60% mortality compared to 100% survival of the WT mice, suggesting higher susceptibility of COX-2 KO mice to sPLA₂-mediated progression of acetaminophen hepatotoxicity. Liver injury was significantly higher at later time points in the KO mice compared to the WT mice indicating that the abatement of progression of injury requires the presence of COX-2. This difference in hepatotoxicity was not due to increased bioactivation of acetaminophen as indicated by unchanged cyp2E1 protein and covalently bound ¹⁴C-APAP in the livers of KO mice. Hepatic sPLA₂ activity and plasma TNF-α were significantly higher after APAP administration in the KO mice. This was accompanied by a corresponding fall in hepatic PGE₂ and lower compensatory liver regeneration and repair (³H-thymidine incorporation) in the KO mice. These results suggest that hindered compensatory tissue repair and poor resolution of inflammation for want of beneficial prostaglandins render the liver very vulnerable to sPLA₂-mediated progression of liver injury. These findings are consistent with the destructive role of sPLA₂ in the progression and expansion of tissue injury as a result of continued hydrolytic breakdown of plasma membrane phospholipids of perinecrotic hepatocytes unless mitigated by sufficient co-induction of COX-2." @default.
• W2013573722 created "2016-06-24" @default.
• W2013573722 creator A5008224944 @default.
• W2013573722 creator A5009402648 @default.
• W2013573722 creator A5030337199 @default.
• W2013573722 creator A5043648150 @default.
• W2013573722 creator A5063381475 @default.
• W2013573722 date "2011-03-01" @default.
• W2013573722 modified "2023-10-01" @default.
• W2013573722 title "Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2" @default.
• W2013573722 cites W1485394752 @default.
• W2013573722 cites W1524754033 @default.
• W2013573722 cites W1537179709 @default.
• W2013573722 cites W1554913031 @default.
• W2013573722 cites W1970277256 @default.
• W2013573722 cites W1983958829 @default.
• W2013573722 cites W1984554579 @default.
• W2013573722 cites W1993226662 @default.
• W2013573722 cites W1993526461 @default.
• W2013573722 cites W1998514068 @default.
• W2013573722 cites W2003428936 @default.
• W2013573722 cites W2006512496 @default.
• W2013573722 cites W2007109180 @default.
• W2013573722 cites W2011072858 @default.
• W2013573722 cites W2012948694 @default.
• W2013573722 cites W2014785656 @default.
• W2013573722 cites W2024658205 @default.
• W2013573722 cites W2028071396 @default.
• W2013573722 cites W2029923221 @default.
• W2013573722 cites W2055721927 @default.
• W2013573722 cites W2056257528 @default.
• W2013573722 cites W2063769966 @default.
• W2013573722 cites W2068403491 @default.
• W2013573722 cites W2070632201 @default.
• W2013573722 cites W2086447779 @default.
• W2013573722 cites W2087073436 @default.
• W2013573722 cites W2088868590 @default.
• W2013573722 cites W2090546037 @default.
• W2013573722 cites W2095290224 @default.
• W2013573722 cites W2097092416 @default.
• W2013573722 cites W2099536385 @default.
• W2013573722 cites W2106423632 @default.
• W2013573722 cites W2145995281 @default.
• W2013573722 cites W2156827860 @default.
• W2013573722 cites W2163790438 @default.
• W2013573722 cites W2165156241 @default.
• W2013573722 cites W2170022255 @default.
• W2013573722 cites W4254687600 @default.
• W2013573722 doi "https://doi.org/10.1016/j.taap.2011.01.013" @default.
• W2013573722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21277885" @default.
• W2013573722 hasPublicationYear "2011" @default.
• W2013573722 type Work @default.
• W2013573722 sameAs 2013573722 @default.
• W2013573722 citedByCount "16" @default.
• W2013573722 countsByYear W20135737222012 @default.
• W2013573722 countsByYear W20135737222013 @default.
• W2013573722 countsByYear W20135737222014 @default.
• W2013573722 countsByYear W20135737222015 @default.
• W2013573722 countsByYear W20135737222016 @default.
• W2013573722 countsByYear W20135737222017 @default.
• W2013573722 countsByYear W20135737222019 @default.
• W2013573722 countsByYear W20135737222021 @default.
• W2013573722 crossrefType "journal-article" @default.
• W2013573722 hasAuthorship W2013573722A5008224944 @default.
• W2013573722 hasAuthorship W2013573722A5009402648 @default.
• W2013573722 hasAuthorship W2013573722A5030337199 @default.
• W2013573722 hasAuthorship W2013573722A5043648150 @default.
• W2013573722 hasAuthorship W2013573722A5063381475 @default.
• W2013573722 hasConcept C126322002 @default.
• W2013573722 hasConcept C12927208 @default.
• W2013573722 hasConcept C134018914 @default.
• W2013573722 hasConcept C140027455 @default.
• W2013573722 hasConcept C181199279 @default.
• W2013573722 hasConcept C185592680 @default.
• W2013573722 hasConcept C2776551241 @default.
• W2013573722 hasConcept C2776637226 @default.
• W2013573722 hasConcept C2776914184 @default.
• W2013573722 hasConcept C2778722691 @default.
• W2013573722 hasConcept C526171541 @default.
• W2013573722 hasConcept C55493867 @default.
• W2013573722 hasConcept C62231903 @default.
• W2013573722 hasConcept C71924100 @default.
• W2013573722 hasConcept C98274493 @default.
• W2013573722 hasConceptScore W2013573722C126322002 @default.
• W2013573722 hasConceptScore W2013573722C12927208 @default.
• W2013573722 hasConceptScore W2013573722C134018914 @default.
• W2013573722 hasConceptScore W2013573722C140027455 @default.
• W2013573722 hasConceptScore W2013573722C181199279 @default.
• W2013573722 hasConceptScore W2013573722C185592680 @default.
• W2013573722 hasConceptScore W2013573722C2776551241 @default.
• W2013573722 hasConceptScore W2013573722C2776637226 @default.
• W2013573722 hasConceptScore W2013573722C2776914184 @default.
• W2013573722 hasConceptScore W2013573722C2778722691 @default.
• W2013573722 hasConceptScore W2013573722C526171541 @default.
• W2013573722 hasConceptScore W2013573722C55493867 @default.
• W2013573722 hasConceptScore W2013573722C62231903 @default.
• W2013573722 hasConceptScore W2013573722C71924100 @default.
• W2013573722 hasConceptScore W2013573722C98274493 @default.

• next