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- W2013577340 abstract "OBJECTIVE: In 9% of cycles, oocyte maturation rate is below 50% and is a reason of concern because it limits the availability of conceptuses for replacement. It may also impair the developmental competence of the mature oocyte cohort. DESIGN: We assessed the clinical outcome of cycles with varying proportions of immature oocytes. MATERIALS AND METHODS: From Sept 1993-Mar 2010, ICSI cycles (n=7867) with ≥8 oocytes retrieved included women ≤35yo and utilizing fresh ejaculated spermatozoa with adequate semen parameters. Cycles were categorized into three groups: minimal (0-33% MII; n=128), adequate (34-66% MII; n=4181), and predominantly mature (67-100%; n=4466). Moreover, only one immature stage, either GV or MI, were assessed over the mature cohort. RESULTS: The average maternal age was 31.8 ± 3yrs. Ejaculated samples yielded a mean density of 54.2 ± 61x106/ml, motility of 36.6 ± 27%, and morphology of 2.8 ± 5%. The fertilization rate was comparable between the adequate (70.0%) and predominantly mature group (74.8%), while it was impaired in the minimal cohort (62.4%, P<0.0001). The clinical pregnancy in the minimal group (31.4%) was also compromised when compared to adequate (41.9%) and predominantly mature groups (50.2%, P<0.0001) and was confirmed in the delivery rate (29.6 vs 39.5 vs 47.8%, respectively, P<0.0001). While the fertilization of the GV only group (77.5%) was higher than the MI only cohort (68.8%, P<0.001), the clinical pregnancy rate was similar. No difference in pregnancy losses was observed. CONCLUSION: It appears that a larger proportion of immature oocytes influenced developmental competence of MII siblings. The most relevant effect was exerted by the presence of MI over GV, however, only on fertilization potential. While the specific MI cohort impairment may have exerted its effect on fertilization through nuclear/cytoplasmic maturational asynchrony, an overwhelming number of immature oocytes limited the conceptuses available for transfer." @default.
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- W2013577340 date "2010-09-01" @default.
- W2013577340 modified "2023-09-30" @default.
- W2013577340 title "Does the proportion of immature oocytes impinge ICSI outcome?" @default.
- W2013577340 doi "https://doi.org/10.1016/j.fertnstert.2010.07.575" @default.
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