Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013580109> ?p ?o ?g. }
- W2013580109 endingPage "6501" @default.
- W2013580109 startingPage "6495" @default.
- W2013580109 abstract "Mammalian hepatitis B viruses encode an essential regulatory protein, termed X, which may also be implicated in liver cancer development associated with chronic infection. X protein, also referred to as HBx in human virus and WHx in woodchuck virus, has been reported to bind to a number of cellular proteins, including the DDB1 subunit of the damaged DNA-binding (DDB) complex. Our previous work provided genetic evidence for the importance of WHx-DDB1 interaction in both the activity of the X protein and establishment of viral infection in woodchucks. In the present study, a direct action of DDB1 on the X protein is documented. Physical interaction between the two proteins leads to an increase in X protein stability. This effect results from protection of the viral protein from proteasome-mediated degradation. Protection of WHx is overcome in the presence DDB2, the second subunit of the DDB heterodimer. In keeping with observations reported for HBx, DDB2 was found to directly bind to WHx. Nonetheless, the counteracting effect of DDB2 on X stabilization requires DDB2-DDB1 interaction. Taken together, these findings substantiate the physical and functional connection between the X protein and the DDB1-DDB2 heterodimer, leading to the regulation of the pool of the viral protein." @default.
- W2013580109 created "2016-06-24" @default.
- W2013580109 creator A5000046252 @default.
- W2013580109 creator A5046653652 @default.
- W2013580109 creator A5066785646 @default.
- W2013580109 date "2002-07-01" @default.
- W2013580109 modified "2023-10-05" @default.
- W2013580109 title "Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex" @default.
- W2013580109 cites W1492288851 @default.
- W2013580109 cites W1525178335 @default.
- W2013580109 cites W1651425720 @default.
- W2013580109 cites W1673668891 @default.
- W2013580109 cites W1799117517 @default.
- W2013580109 cites W1832030339 @default.
- W2013580109 cites W1980134555 @default.
- W2013580109 cites W1997615901 @default.
- W2013580109 cites W1997871326 @default.
- W2013580109 cites W2003645332 @default.
- W2013580109 cites W2005383067 @default.
- W2013580109 cites W2008561915 @default.
- W2013580109 cites W2010142538 @default.
- W2013580109 cites W2016941152 @default.
- W2013580109 cites W2020294551 @default.
- W2013580109 cites W2034030391 @default.
- W2013580109 cites W2034116029 @default.
- W2013580109 cites W2034449856 @default.
- W2013580109 cites W2034626290 @default.
- W2013580109 cites W2036515140 @default.
- W2013580109 cites W2038352482 @default.
- W2013580109 cites W2043897928 @default.
- W2013580109 cites W2061369977 @default.
- W2013580109 cites W2061941585 @default.
- W2013580109 cites W2065851935 @default.
- W2013580109 cites W2067627888 @default.
- W2013580109 cites W2070580124 @default.
- W2013580109 cites W2073658506 @default.
- W2013580109 cites W2082167075 @default.
- W2013580109 cites W2093813815 @default.
- W2013580109 cites W2096808350 @default.
- W2013580109 cites W2109654261 @default.
- W2013580109 cites W2112066280 @default.
- W2013580109 cites W2113724086 @default.
- W2013580109 cites W2116298148 @default.
- W2013580109 cites W2136470788 @default.
- W2013580109 cites W2147842298 @default.
- W2013580109 cites W2154110339 @default.
- W2013580109 cites W2155468974 @default.
- W2013580109 cites W2164769035 @default.
- W2013580109 cites W2166826446 @default.
- W2013580109 cites W2170634115 @default.
- W2013580109 cites W2313258877 @default.
- W2013580109 cites W2313812873 @default.
- W2013580109 cites W2327798355 @default.
- W2013580109 cites W2332269749 @default.
- W2013580109 cites W2394686823 @default.
- W2013580109 cites W3101072197 @default.
- W2013580109 doi "https://doi.org/10.1128/jvi.76.13.6495-6501.2002" @default.
- W2013580109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136256" @default.
- W2013580109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12050362" @default.
- W2013580109 hasPublicationYear "2002" @default.
- W2013580109 type Work @default.
- W2013580109 sameAs 2013580109 @default.
- W2013580109 citedByCount "58" @default.
- W2013580109 countsByYear W20135801092012 @default.
- W2013580109 countsByYear W20135801092013 @default.
- W2013580109 countsByYear W20135801092014 @default.
- W2013580109 countsByYear W20135801092015 @default.
- W2013580109 countsByYear W20135801092016 @default.
- W2013580109 countsByYear W20135801092017 @default.
- W2013580109 countsByYear W20135801092018 @default.
- W2013580109 countsByYear W20135801092019 @default.
- W2013580109 countsByYear W20135801092020 @default.
- W2013580109 countsByYear W20135801092021 @default.
- W2013580109 crossrefType "journal-article" @default.
- W2013580109 hasAuthorship W2013580109A5000046252 @default.
- W2013580109 hasAuthorship W2013580109A5046653652 @default.
- W2013580109 hasAuthorship W2013580109A5066785646 @default.
- W2013580109 hasBestOaLocation W20135801091 @default.
- W2013580109 hasConcept C104292427 @default.
- W2013580109 hasConcept C104317684 @default.
- W2013580109 hasConcept C140248907 @default.
- W2013580109 hasConcept C153911025 @default.
- W2013580109 hasConcept C159047783 @default.
- W2013580109 hasConcept C180196505 @default.
- W2013580109 hasConcept C2522874641 @default.
- W2013580109 hasConcept C2780593183 @default.
- W2013580109 hasConcept C2780617729 @default.
- W2013580109 hasConcept C2781079990 @default.
- W2013580109 hasConcept C2992195973 @default.
- W2013580109 hasConcept C54355233 @default.
- W2013580109 hasConcept C67567795 @default.
- W2013580109 hasConcept C86339819 @default.
- W2013580109 hasConcept C86803240 @default.
- W2013580109 hasConcept C94966510 @default.
- W2013580109 hasConcept C95444343 @default.
- W2013580109 hasConceptScore W2013580109C104292427 @default.
- W2013580109 hasConceptScore W2013580109C104317684 @default.
- W2013580109 hasConceptScore W2013580109C140248907 @default.