FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013583560> ?p ?o ?g. }

• W2013583560 endingPage "123" @default.
• W2013583560 startingPage "112" @default.
• W2013583560 abstract "<i>Background:</i> NADPH oxidase is an important enzyme involved in the generation of reactive oxygen species in acute kidney injury (AKI). Its key subunit, p22^phox, is encoded by the highly polymorphic <i>CYBA</i> gene. <i>Methods:</i> We examined the associations of <i>CYBA </i>gene polymorphisms across the <i>CYBA </i>locus (rs8854, rs3794624, rs4673, rs4782390, and rs1049255) with dialysis requirement or in-hospital death in 256 hospitalized adults with AKI. Dominant and haplotype multivariable logistic regression analyses were performed, adjusted for sex, race, age, and severity of illness. <i>Results:</i> The baseline characteristics of the patients were not different among genotype groups with the exception of a lower prevalence of sepsis and shock in the <i>CYBA</i> rs8854 A-allele group; a higher prevalence of shock in the <i>CYBA</i> rs4782390 T-allele group, and a higher APACHE II score in the <i>CYBA </i>rs1049255 G-allele group. The <i>CYBA</i> rs8854 A-allele had an adjusted odds ratio (OR) of 0.41 (95% confidence interval, CI, 0.18–0.96) for the outcome of dialysis requirement or in-hospital death. The <i>CYBA</i> rs4673 T-allele and rs1049255 G-allele had unadjusted ORs of 1.69 (95% CI 1.03–2.79) and 1.66 (95% CI 1.01–2.73) for the composite outcome, respectively, which became non-significant after multivariable adjustment. The remaining 2 polymorphisms were not associated with the outcomes of interest. Finally, the presence of the <i>CYBA</i> A-A-G-G haplotype (generated from rs4782390, rs4673, rs3794624, and rs8854, all in Hardy-Weinberg equilibrium) was associated with an elevated OR of 1.81 (95% CI 1.07–3.08) for dialysis requirement or in-hospital death, which was attenuated after multivariable adjustment (OR 1.80; 95% CI 0.99–3.29). <i>Conclusion:</i> This study identifies several polymorphisms spanning the entire <i>CYBA</i> gene locus and a common haplotype as risk markers for dialysis requirement or in-hospital death in patients with AKI. Additional studies are needed to validate these findings." @default.
• W2013583560 created "2016-06-24" @default.
• W2013583560 creator A5008411489 @default.
• W2013583560 creator A5025127395 @default.
• W2013583560 creator A5060070231 @default.
• W2013583560 creator A5061553198 @default.
• W2013583560 creator A5066015692 @default.
• W2013583560 creator A5074694483 @default.
• W2013583560 date "2011-01-01" @default.
• W2013583560 modified "2023-10-16" @default.
• W2013583560 title "<i>CYBA</i> Gene Polymorphisms and Adverse Outcomes in Acute Kidney Injury: A Prospective Cohort Study" @default.
• W2013583560 cites W1570583 @default.
• W2013583560 cites W1956687039 @default.
• W2013583560 cites W1967300023 @default.
• W2013583560 cites W1986328934 @default.
• W2013583560 cites W1992547614 @default.
• W2013583560 cites W2007649401 @default.
• W2013583560 cites W2008056331 @default.
• W2013583560 cites W2013005096 @default.
• W2013583560 cites W2019443107 @default.
• W2013583560 cites W2020955718 @default.
• W2013583560 cites W2021411442 @default.
• W2013583560 cites W2047474179 @default.
• W2013583560 cites W2052952920 @default.
• W2013583560 cites W2055864845 @default.
• W2013583560 cites W2057692399 @default.
• W2013583560 cites W2071331336 @default.
• W2013583560 cites W2084521240 @default.
• W2013583560 cites W2087203965 @default.
• W2013583560 cites W2097640358 @default.
• W2013583560 cites W2098990645 @default.
• W2013583560 cites W2100339818 @default.
• W2013583560 cites W2101015806 @default.
• W2013583560 cites W2105042843 @default.
• W2013583560 cites W2107104581 @default.
• W2013583560 cites W2107777934 @default.
• W2013583560 cites W2121632745 @default.
• W2013583560 cites W2123799914 @default.
• W2013583560 cites W2130499084 @default.
• W2013583560 cites W2131419242 @default.
• W2013583560 cites W2132287412 @default.
• W2013583560 cites W2140728070 @default.
• W2013583560 cites W2151527793 @default.
• W2013583560 cites W2152193452 @default.
• W2013583560 cites W2171273880 @default.
• W2013583560 cites W2171815293 @default.
• W2013583560 cites W2418588845 @default.
• W2013583560 cites W2107978811 @default.
• W2013583560 doi "https://doi.org/10.1159/000333017" @default.
• W2013583560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3290849" @default.
• W2013583560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22470385" @default.
• W2013583560 hasPublicationYear "2011" @default.
• W2013583560 type Work @default.
• W2013583560 sameAs 2013583560 @default.
• W2013583560 citedByCount "6" @default.
• W2013583560 countsByYear W20135835602012 @default.
• W2013583560 countsByYear W20135835602013 @default.
• W2013583560 countsByYear W20135835602014 @default.
• W2013583560 countsByYear W20135835602015 @default.
• W2013583560 countsByYear W20135835602018 @default.
• W2013583560 countsByYear W20135835602021 @default.
• W2013583560 crossrefType "journal-article" @default.
• W2013583560 hasAuthorship W2013583560A5008411489 @default.
• W2013583560 hasAuthorship W2013583560A5025127395 @default.
• W2013583560 hasAuthorship W2013583560A5060070231 @default.
• W2013583560 hasAuthorship W2013583560A5061553198 @default.
• W2013583560 hasAuthorship W2013583560A5066015692 @default.
• W2013583560 hasAuthorship W2013583560A5074694483 @default.
• W2013583560 hasBestOaLocation W20135835601 @default.
• W2013583560 hasConcept C104317684 @default.
• W2013583560 hasConcept C126322002 @default.
• W2013583560 hasConcept C177713679 @default.
• W2013583560 hasConcept C188816634 @default.
• W2013583560 hasConcept C194828623 @default.
• W2013583560 hasConcept C197934379 @default.
• W2013583560 hasConcept C201903717 @default.
• W2013583560 hasConcept C2780472472 @default.
• W2013583560 hasConcept C54355233 @default.
• W2013583560 hasConcept C71924100 @default.
• W2013583560 hasConcept C72563966 @default.
• W2013583560 hasConcept C86803240 @default.
• W2013583560 hasConceptScore W2013583560C104317684 @default.
• W2013583560 hasConceptScore W2013583560C126322002 @default.
• W2013583560 hasConceptScore W2013583560C177713679 @default.
• W2013583560 hasConceptScore W2013583560C188816634 @default.
• W2013583560 hasConceptScore W2013583560C194828623 @default.
• W2013583560 hasConceptScore W2013583560C197934379 @default.
• W2013583560 hasConceptScore W2013583560C201903717 @default.
• W2013583560 hasConceptScore W2013583560C2780472472 @default.
• W2013583560 hasConceptScore W2013583560C54355233 @default.
• W2013583560 hasConceptScore W2013583560C71924100 @default.
• W2013583560 hasConceptScore W2013583560C72563966 @default.
• W2013583560 hasConceptScore W2013583560C86803240 @default.
• W2013583560 hasIssue "1" @default.
• W2013583560 hasLocation W20135835601 @default.
• W2013583560 hasLocation W20135835602 @default.
• W2013583560 hasLocation W20135835603 @default.
• W2013583560 hasLocation W20135835604 @default.

• next