Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013586507> ?p ?o ?g. }
- W2013586507 endingPage "1979" @default.
- W2013586507 startingPage "1979" @default.
- W2013586507 abstract "Mecobalamin, a form of vitamin B12 containing a central metal element (cobalt), is one of the most important mediators of nervous system function. In the clinic, it is often used to accelerate recovery of peripheral nerves, but its molecular mechanism remains unclear. In the present study, we performed sciatic nerve crush injury in mice, followed by daily intraperitoneal administration of mecobalamin (65 μg/kg or 130 μg/kg) or saline (negative control). Walking track analysis, histomorphological examination, and quantitative real-time PCR showed that mecobalamin significantly improved functional recovery of the sciatic nerve, thickened the myelin sheath in myelinated nerve fibers, and increased the cross-sectional area of target muscle cells. Furthermore, mecobalamin upregulated mRNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury, and of neurotrophic factors (nerve growth factor, brain-derived nerve growth factor and ciliary neurotrophic factor) in the L4–6 dorsal root ganglia. Our findings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes." @default.
- W2013586507 created "2016-06-24" @default.
- W2013586507 creator A5013314369 @default.
- W2013586507 creator A5013925449 @default.
- W2013586507 creator A5045067652 @default.
- W2013586507 creator A5054351096 @default.
- W2013586507 creator A5057687827 @default.
- W2013586507 creator A5062661590 @default.
- W2013586507 creator A5071573548 @default.
- W2013586507 date "2014-01-01" @default.
- W2013586507 modified "2023-10-02" @default.
- W2013586507 title "Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice" @default.
- W2013586507 cites W1505955782 @default.
- W2013586507 cites W1831979211 @default.
- W2013586507 cites W1834007910 @default.
- W2013586507 cites W1950689805 @default.
- W2013586507 cites W1968969456 @default.
- W2013586507 cites W1972900653 @default.
- W2013586507 cites W1976374480 @default.
- W2013586507 cites W1977225074 @default.
- W2013586507 cites W1988580985 @default.
- W2013586507 cites W1997028439 @default.
- W2013586507 cites W2002253709 @default.
- W2013586507 cites W2007147601 @default.
- W2013586507 cites W2014911628 @default.
- W2013586507 cites W2016470847 @default.
- W2013586507 cites W2019602403 @default.
- W2013586507 cites W2023903401 @default.
- W2013586507 cites W2026506780 @default.
- W2013586507 cites W2026757435 @default.
- W2013586507 cites W2051083978 @default.
- W2013586507 cites W2051133214 @default.
- W2013586507 cites W2053858145 @default.
- W2013586507 cites W2065994644 @default.
- W2013586507 cites W2067983175 @default.
- W2013586507 cites W2077085462 @default.
- W2013586507 cites W2080257722 @default.
- W2013586507 cites W2085729128 @default.
- W2013586507 cites W2093760230 @default.
- W2013586507 cites W2101881897 @default.
- W2013586507 cites W2103706525 @default.
- W2013586507 cites W2105785463 @default.
- W2013586507 cites W2107277218 @default.
- W2013586507 cites W2112910931 @default.
- W2013586507 cites W2113183626 @default.
- W2013586507 cites W2124473840 @default.
- W2013586507 cites W2127581110 @default.
- W2013586507 cites W2129431919 @default.
- W2013586507 cites W2142254746 @default.
- W2013586507 cites W2159327905 @default.
- W2013586507 cites W2168867243 @default.
- W2013586507 cites W2192080449 @default.
- W2013586507 cites W2323212320 @default.
- W2013586507 cites W2328487515 @default.
- W2013586507 cites W2332374030 @default.
- W2013586507 cites W2469769652 @default.
- W2013586507 cites W2522558067 @default.
- W2013586507 cites W2949197872 @default.
- W2013586507 doi "https://doi.org/10.4103/1673-5374.145379" @default.
- W2013586507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4283280" @default.
- W2013586507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25598780" @default.
- W2013586507 hasPublicationYear "2014" @default.
- W2013586507 type Work @default.
- W2013586507 sameAs 2013586507 @default.
- W2013586507 citedByCount "23" @default.
- W2013586507 countsByYear W20135865072014 @default.
- W2013586507 countsByYear W20135865072015 @default.
- W2013586507 countsByYear W20135865072016 @default.
- W2013586507 countsByYear W20135865072017 @default.
- W2013586507 countsByYear W20135865072018 @default.
- W2013586507 countsByYear W20135865072020 @default.
- W2013586507 countsByYear W20135865072021 @default.
- W2013586507 countsByYear W20135865072022 @default.
- W2013586507 countsByYear W20135865072023 @default.
- W2013586507 crossrefType "journal-article" @default.
- W2013586507 hasAuthorship W2013586507A5013314369 @default.
- W2013586507 hasAuthorship W2013586507A5013925449 @default.
- W2013586507 hasAuthorship W2013586507A5045067652 @default.
- W2013586507 hasAuthorship W2013586507A5054351096 @default.
- W2013586507 hasAuthorship W2013586507A5057687827 @default.
- W2013586507 hasAuthorship W2013586507A5062661590 @default.
- W2013586507 hasAuthorship W2013586507A5071573548 @default.
- W2013586507 hasBestOaLocation W20135865071 @default.
- W2013586507 hasConcept C104317684 @default.
- W2013586507 hasConcept C126322002 @default.
- W2013586507 hasConcept C127561419 @default.
- W2013586507 hasConcept C141071460 @default.
- W2013586507 hasConcept C160539049 @default.
- W2013586507 hasConcept C170493617 @default.
- W2013586507 hasConcept C185592680 @default.
- W2013586507 hasConcept C185856081 @default.
- W2013586507 hasConcept C2775991916 @default.
- W2013586507 hasConcept C2776588550 @default.
- W2013586507 hasConcept C2776880756 @default.
- W2013586507 hasConcept C2777107032 @default.
- W2013586507 hasConcept C2778423431 @default.
- W2013586507 hasConcept C2778790584 @default.
- W2013586507 hasConcept C2781149210 @default.