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- W2013595040 abstract "AbstractTo determine whether adriamycin (ADR) and/or its metabolites undergo an enterohepatic circulation following an iv administration, anesthetized rats with biliary and urinary fistulae were intraduodenally perfused with bile flowing from bile duct-cannulated rats which had been injected iv with 20 mg/kg [14C]ADR. During a 6-hr duodenal perfusion period, 27.3% of the ADR injected to bile donor rats was recovered as total radioactivity in the intestinal perfusate of bile recipient rats and approximately 1.6 and 0.18% were excreted in their bile and urine, respectively. The intestinal tissue of bile recipient rats contained concentrations of the total drug equivalents ranging from 1.98 μg/g in the initial portions of the duodenum to 12.21 μg/g in the distal parts of the ileum. Minimal levels were observed in the heart, lung, kidney, and liver (0.25–0.86 μg/g tissue). In order to estimate the amount of the total [14C]ADR equivalents perfused into the small intestine of the bile recipient rats, [14C]ADR 2..." @default.
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- W2013595040 date "1982-01-01" @default.
- W2013595040 modified "2023-09-27" @default.
- W2013595040 title "Does Adriamycin Undergo an Enterohepatic Circulation?" @default.
- W2013595040 doi "https://doi.org/10.3181/00379727-169-41304" @default.
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