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• W2013598275 abstract "This Letter describes the continued optimization of an MLPCN probe molecule (ML137) with a focused effort on the replacement/modification of the isatin moiety present in this highly selective M(1) PAM. A diverse range of structures were validated as viable replacements for the isatin, many of which engendered sizeable improvements in their ability to enhance the potency and efficacy of acetylcholine when compared to ML137. Muscarinic receptor subtype selectivity for the M(1) receptor was also maintained." @default.
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• W2013598275 date "2013-01-01" @default.
• W2013598275 modified "2023-09-24" @default.
• W2013598275 title "Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule" @default.
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• W2013598275 doi "https://doi.org/10.1016/j.bmcl.2012.11.092" @default.
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