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- W2013599794 abstract "When investigating tetanus lethality summation curves of mice under comparable quantitative conditions following a temporarily limited administration of penicillin, the curves obtained can be calculated by the kinetics of tumour cells or wound fibroblasts. In particular, it has been shown that the optimal efficacy of penicillin, after short-time usage as compared with a long-time administration schedule, is determined by the generation time of the tetanus rods as a function of the mitotic cycle of the “pace-making” tumour cells or wound fibroblasts. Further variables of the mathematical model imply the pharmacokinetics of penicillin and the recovery process of the “hit” tetanus rods. From these results some basic experimental and clinical tetanus issues can be elucidated; thus, the mitosis theory of tetanus is being verified for the stage of incubation and of clinical manifestation, while the classical necrosis theory of the pathogenesis of tetanus infection should be valid only for the final stage. Untersucht man die Tetarius-Summen-Sterbekurven von Mäusen unter vergleichbaren quantitativen Bedingungen, so führt eine zeitlich limitierte Penicillin-Applikation zu Kurvenverläufen, die sich mit der Kinetik der Tumorzellen bzw. Wundfibroblasten berechnen lassen. Insbesondere kann gezeigt werden, daß der optimale Penicillin-Effekt nach Kurzzeit-Applikation, verglichen mit einer Langzeit-Dosierung, von der Generationszeit der Tetanusstäbchen als Funktion des Mitose-Zyklus der “schrittmachenden” Tumorzellen oder Wundfibroblasten bestimmt wird. Weitere Einflußgrößen des mathematischen Modells sind die Pharmakokinetik des Penicillins und Erholungsprozesse der “getroffenen” Tetanus-Stäbchen. Die Ergebnisse der Modellversuche helfen, einige umstrittene Grundansichten experimenteller und klinischer Tetanusfragen aufzuhellen. Sie verifizieren die Mitose-Theorie des Tetanus für die Inkubation und klinische Manifestation. Die klassische Nekrose-Theorie der Tetanus-Pathogenese dürfte lediglich für das Finalstadium zutreffen." @default.
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- W2013599794 date "1987-10-01" @default.
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- W2013599794 title "The role of cell population kinetics in the efficacy of penicillin — An experimental analysis and stochastic modeling of the tumour tetanus and wound tetanus of the mouse" @default.
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- W2013599794 doi "https://doi.org/10.1016/s0176-6724(87)80233-x" @default.
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