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• W2013600410 abstract "Keap1–Nrf2 pathway has emerged as a regulator for the endogenous antioxidant response, which is critical in defending cells against carcinogenesis. Herein, we demonstrated that depleting the cellular level of glutathione (GSH) by a novel electrophilic agent 2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene (PYDDT) could activate Keap1–Nrf2 pathway. In above process, it was found that Keap1 was modified by S-glutathionylation, an important post-translational modification of protein cysteines with critical roles in oxidative stress and signal transduction. We concluded from our findings that conjugation with intracellular GSH by PYDDT might lead to Keap1 S-glutathionylation and was a key event involved in its Nrf2 inducing activity." @default.
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• W2013600410 date "2010-11-01" @default.
• W2013600410 modified "2023-10-16" @default.
• W2013600410 title "PYDDT, a novel phase 2 enzymes inducer, activates Keap1–Nrf2 pathway via depleting the cellular level of glutathione" @default.
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• W2013600410 doi "https://doi.org/10.1016/j.toxlet.2010.08.011" @default.
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