FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013600510> ?p ?o ?g. }

• W2013600510 endingPage "1126" @default.
• W2013600510 startingPage "1119" @default.
• W2013600510 abstract "Background: Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels. Given the difference in allele frequencies and linkage disequilibrium patterns across the populations, a GWAS was conducted using the Illumina 550K in a Japanese population (n=900) in search of population-specific genetic variations associated with high-density lipoprotein (HDL)-cholesterol. Methods and Results: Among the 368,274 single nucleotide polymorphisms (SNPs) with a minor allele frequency of at least 0.1, 43 SNPs exceeded the arbitrary threshold of -log10P >4.0. The most significant SNP was rs3764261, located 5'upstream of CETP, exhibiting a -log10P value of 6.17. Increasing the sample size by genotyping in the additional Suita sample (n=1,810) further improved the level of significance, with each additional copy of the minor allele being associated with an increase in HDL-cholesterol by 6.2 mg/dl (P =3.4×10-12). Interestingly, the minor allele was more prevalent in cases with myocardial infarction than in controls (0.221 vs 0.196, nominal P=0.02). Conclusions: The association between genetic variants at CETP and HDL-cholesterol was replicated in our sample. None of the genetic variants exerted a greater influence on HDL levels than those at CETP. Associations for the top-ranked SNPs need to be tested for further replication in an independent sample. (Circ J 2009; 73: 1119-1126)" @default.
• W2013600510 created "2016-06-24" @default.
• W2013600510 creator A5010599130 @default.
• W2013600510 creator A5018175714 @default.
• W2013600510 creator A5028723664 @default.
• W2013600510 creator A5039090244 @default.
• W2013600510 creator A5040372143 @default.
• W2013600510 creator A5047837943 @default.
• W2013600510 creator A5057200745 @default.
• W2013600510 creator A5064905150 @default.
• W2013600510 creator A5065308273 @default.
• W2013600510 creator A5066782777 @default.
• W2013600510 creator A5091549956 @default.
• W2013600510 date "2009-01-01" @default.
• W2013600510 modified "2023-10-15" @default.
• W2013600510 title "Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population The Suita Study" @default.
• W2013600510 cites W1499959019 @default.
• W2013600510 cites W1927556662 @default.
• W2013600510 cites W1971481668 @default.
• W2013600510 cites W1976771981 @default.
• W2013600510 cites W1991088942 @default.
• W2013600510 cites W2006159661 @default.
• W2013600510 cites W2013731962 @default.
• W2013600510 cites W2015849111 @default.
• W2013600510 cites W2021752512 @default.
• W2013600510 cites W2022109882 @default.
• W2013600510 cites W2024629993 @default.
• W2013600510 cites W2025143098 @default.
• W2013600510 cites W2036198235 @default.
• W2013600510 cites W2036572353 @default.
• W2013600510 cites W2037252383 @default.
• W2013600510 cites W2043154979 @default.
• W2013600510 cites W2044894031 @default.
• W2013600510 cites W2048755332 @default.
• W2013600510 cites W2048760408 @default.
• W2013600510 cites W2054140695 @default.
• W2013600510 cites W2056226184 @default.
• W2013600510 cites W2060090217 @default.
• W2013600510 cites W2068238693 @default.
• W2013600510 cites W2073841042 @default.
• W2013600510 cites W2077760013 @default.
• W2013600510 cites W2094058959 @default.
• W2013600510 cites W2111847103 @default.
• W2013600510 cites W2115105579 @default.
• W2013600510 cites W2122049307 @default.
• W2013600510 cites W2123782003 @default.
• W2013600510 cites W2134543673 @default.
• W2013600510 cites W2134783591 @default.
• W2013600510 cites W2142769596 @default.
• W2013600510 cites W2162530578 @default.
• W2013600510 cites W2163012157 @default.
• W2013600510 cites W2336122760 @default.
• W2013600510 doi "https://doi.org/10.1253/circj.cj-08-1101" @default.
• W2013600510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19359809" @default.
• W2013600510 hasPublicationYear "2009" @default.
• W2013600510 type Work @default.
• W2013600510 sameAs 2013600510 @default.
• W2013600510 citedByCount "47" @default.
• W2013600510 countsByYear W20136005102012 @default.
• W2013600510 countsByYear W20136005102013 @default.
• W2013600510 countsByYear W20136005102014 @default.
• W2013600510 countsByYear W20136005102015 @default.
• W2013600510 countsByYear W20136005102016 @default.
• W2013600510 countsByYear W20136005102017 @default.
• W2013600510 countsByYear W20136005102018 @default.
• W2013600510 countsByYear W20136005102019 @default.
• W2013600510 countsByYear W20136005102022 @default.
• W2013600510 crossrefType "journal-article" @default.
• W2013600510 hasAuthorship W2013600510A5010599130 @default.
• W2013600510 hasAuthorship W2013600510A5018175714 @default.
• W2013600510 hasAuthorship W2013600510A5028723664 @default.
• W2013600510 hasAuthorship W2013600510A5039090244 @default.
• W2013600510 hasAuthorship W2013600510A5040372143 @default.
• W2013600510 hasAuthorship W2013600510A5047837943 @default.
• W2013600510 hasAuthorship W2013600510A5057200745 @default.
• W2013600510 hasAuthorship W2013600510A5064905150 @default.
• W2013600510 hasAuthorship W2013600510A5065308273 @default.
• W2013600510 hasAuthorship W2013600510A5066782777 @default.
• W2013600510 hasAuthorship W2013600510A5091549956 @default.
• W2013600510 hasBestOaLocation W20136005101 @default.
• W2013600510 hasConcept C104317684 @default.
• W2013600510 hasConcept C106208931 @default.
• W2013600510 hasConcept C135763542 @default.
• W2013600510 hasConcept C139275648 @default.
• W2013600510 hasConcept C153209595 @default.
• W2013600510 hasConcept C157410074 @default.
• W2013600510 hasConcept C180754005 @default.
• W2013600510 hasConcept C186413461 @default.
• W2013600510 hasConcept C2908647359 @default.
• W2013600510 hasConcept C31467283 @default.
• W2013600510 hasConcept C35605836 @default.
• W2013600510 hasConcept C37463918 @default.
• W2013600510 hasConcept C54355233 @default.
• W2013600510 hasConcept C71924100 @default.
• W2013600510 hasConcept C86803240 @default.
• W2013600510 hasConcept C99454951 @default.
• W2013600510 hasConceptScore W2013600510C104317684 @default.
• W2013600510 hasConceptScore W2013600510C106208931 @default.

• next