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• W2013606098 abstract "A comprehensive survey of class I α-tubulin (αl) and class II β-tubulin (βII) mRNAs was performed using in situ hybridization in order to determine the extent of continued expression of these immature tubulin isotype mRNAs in the adult rat brain. Qualitatively similar distributions of the two isotype mRNAs were observed, with marked variations in hybridization intensity of both probes apparent across different brain regions. Neurons in a wide variety of structures throughout the brain exhibited intense hybridization signals. While the presence of large numbers of neurons with a moderate hybridization intensity could account for the relatively high level of total binding in some regions such as the cerebellar and dentate granule layers, in most cases higher regional mRNA levels reflected greater hybridization intensity per neuron. Little variability in hybridization intensity was typically seen between individual cells within specific nuclei throughout the brain. The presence of occasional intensely labeled neurons scattered throughout the basal ganglia provided the most striking exception to this pattern. While no qualitative differences between the distributions of αl-tubulin and βII-tubulin mRNAs were observed, consistent differences in the relative intensity of hybridization for α1-tubulin versus βII-tubulin mRNA were apparent in a few brain regions. Expression by glia did not appear to contribute significantly to detectable levels of either α1-tubulin or βII-tubulin mRNA. These findings suggest that continued expression of growth-associated tubulin isotype mRNAs may have functional significance in specific neuronal populations of the adult brain. Partial overlap between the distributions of α1- and βII-tubulin mRNAs and that of GAP-43 mRNA is discussed, as are potential roles for growth-associated tubulin gene expression in supporting cytoskeletal turnover, reactive axonal growth, and dendritic remodeling in the adult brain. © 1995 Wiley-Liss Inc." @default.
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• W2013606098 date "1995-11-20" @default.
• W2013606098 modified "2023-09-24" @default.
• W2013606098 title "Distribution of growth-associated class I ?-tubulin and class II ?-tubulin mrnas in adult rat brain" @default.
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• W2013606098 doi "https://doi.org/10.1002/cne.903620306" @default.
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