Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013606687> ?p ?o ?g. }
- W2013606687 endingPage "521" @default.
- W2013606687 startingPage "509" @default.
- W2013606687 abstract "Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of spinal cord, brainstem, and cortical motor neurons. In a minority of patients, the disease is caused by mutations in the copper (2+)/zinc (2+) superoxide dismutase 1 (SOD1) gene. Recent evidence suggests that astrocytes are dysfunctional in ALS and may be a critical link in the support of motor neuron health. Furthermore, growth factors, such as glial cell line-derived neurotrophic factor (GDNF), have a high affinity for motor neurons and can prevent their death following various insults, but due to the protein's large size are difficult to directly administer to brain. In this study, human neural progenitor cells (hNPC) isolated from the cortex were expanded in culture and modified using lentivirus to secrete GDNF (hNPCGDNF). These cells survived up to 11 weeks following transplantation into the lumbar spinal cord of rats overexpressing the G93A SOD1 mutation (SOD1G93A). Cellular integration into both gray and white matter was observed without adverse behavioral effects. All transplants secreted GDNF within the region of cell survival, but not outside this area. Fibers were seen to upregulate cholinergic markers in response to GDNF, indicating it was physiologically active. We conclude that genetically modified hNPC can survive, integrate, and release GDNF in the spinal cord of SOD1G93A rats. As such, they provide an interesting source of cells for both glial replacement and trophic factor delivery in future human clinical studies." @default.
- W2013606687 created "2016-06-24" @default.
- W2013606687 creator A5001356149 @default.
- W2013606687 creator A5024785453 @default.
- W2013606687 creator A5025813209 @default.
- W2013606687 creator A5029219832 @default.
- W2013606687 creator A5030225005 @default.
- W2013606687 creator A5040634756 @default.
- W2013606687 creator A5067326029 @default.
- W2013606687 creator A5076105306 @default.
- W2013606687 date "2005-04-01" @default.
- W2013606687 modified "2023-10-12" @default.
- W2013606687 title "GDNF Delivery Using Human Neural Progenitor Cells in a Rat Model of ALS" @default.
- W2013606687 cites W1503270785 @default.
- W2013606687 cites W1555605403 @default.
- W2013606687 cites W1595834812 @default.
- W2013606687 cites W1844154778 @default.
- W2013606687 cites W1916238061 @default.
- W2013606687 cites W1940519961 @default.
- W2013606687 cites W1948919957 @default.
- W2013606687 cites W1964451213 @default.
- W2013606687 cites W1971639674 @default.
- W2013606687 cites W1976366566 @default.
- W2013606687 cites W1977907679 @default.
- W2013606687 cites W1979517834 @default.
- W2013606687 cites W1985660222 @default.
- W2013606687 cites W1988849173 @default.
- W2013606687 cites W1988878898 @default.
- W2013606687 cites W1988931872 @default.
- W2013606687 cites W1989464571 @default.
- W2013606687 cites W1992267774 @default.
- W2013606687 cites W1996001296 @default.
- W2013606687 cites W1996117064 @default.
- W2013606687 cites W2002104055 @default.
- W2013606687 cites W2003322030 @default.
- W2013606687 cites W2008560021 @default.
- W2013606687 cites W2013135033 @default.
- W2013606687 cites W2015266340 @default.
- W2013606687 cites W2018202764 @default.
- W2013606687 cites W2019452853 @default.
- W2013606687 cites W2025792719 @default.
- W2013606687 cites W2035133362 @default.
- W2013606687 cites W2035831169 @default.
- W2013606687 cites W2041463273 @default.
- W2013606687 cites W2042169537 @default.
- W2013606687 cites W2046450144 @default.
- W2013606687 cites W2057962057 @default.
- W2013606687 cites W2060572966 @default.
- W2013606687 cites W2062854702 @default.
- W2013606687 cites W2064640860 @default.
- W2013606687 cites W2064982871 @default.
- W2013606687 cites W2085409671 @default.
- W2013606687 cites W2089359260 @default.
- W2013606687 cites W2090227048 @default.
- W2013606687 cites W2092034907 @default.
- W2013606687 cites W2092398155 @default.
- W2013606687 cites W2096386031 @default.
- W2013606687 cites W2097066519 @default.
- W2013606687 cites W2101910698 @default.
- W2013606687 cites W2106526071 @default.
- W2013606687 cites W2107768418 @default.
- W2013606687 cites W2108724455 @default.
- W2013606687 cites W2111016560 @default.
- W2013606687 cites W2111769538 @default.
- W2013606687 cites W2117058176 @default.
- W2013606687 cites W2122082144 @default.
- W2013606687 cites W2123016546 @default.
- W2013606687 cites W2123402756 @default.
- W2013606687 cites W2123779560 @default.
- W2013606687 cites W2124976615 @default.
- W2013606687 cites W2128744963 @default.
- W2013606687 cites W2134024013 @default.
- W2013606687 cites W2135522980 @default.
- W2013606687 cites W2136310938 @default.
- W2013606687 cites W2137440275 @default.
- W2013606687 cites W2149497936 @default.
- W2013606687 cites W2150922307 @default.
- W2013606687 cites W2154549928 @default.
- W2013606687 cites W2161428438 @default.
- W2013606687 cites W2165526364 @default.
- W2013606687 cites W2170645579 @default.
- W2013606687 cites W2173520530 @default.
- W2013606687 cites W2178932096 @default.
- W2013606687 doi "https://doi.org/10.1089/hum.2005.16.509" @default.
- W2013606687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15871682" @default.
- W2013606687 hasPublicationYear "2005" @default.
- W2013606687 type Work @default.
- W2013606687 sameAs 2013606687 @default.
- W2013606687 citedByCount "246" @default.
- W2013606687 countsByYear W20136066872012 @default.
- W2013606687 countsByYear W20136066872013 @default.
- W2013606687 countsByYear W20136066872014 @default.
- W2013606687 countsByYear W20136066872015 @default.
- W2013606687 countsByYear W20136066872016 @default.
- W2013606687 countsByYear W20136066872017 @default.
- W2013606687 countsByYear W20136066872018 @default.
- W2013606687 countsByYear W20136066872019 @default.
- W2013606687 countsByYear W20136066872020 @default.