FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013607445> ?p ?o ?g. }

• W2013607445 abstract "Knockout of the Cyp-19 gene (aromatase) renders mice to have insufficient endogenous estrogen production and contributes to the development of symptoms related the metabolic syndrome, including excess adiposity and insulin resistance. This study comparatively assessed the estrogen responsiveness in animal models of genetical versus surgical (ovariectomy) origin of estrogen deficiency. Evaluation of physiological parameters and gene expression pattern in response to estrogens revealed differences in estrogen responsiveness between aromatase deficient and castrated or intact wild-type mice. ArKO mice had a significantly higher bodyweight than matched ovariectomized wild-type mice. The weight of the completely regressed uterus following ovariectomy was higher than the uterine weight of ArKO mice. Further, alterations in metabolic parameters like increased serum leptin levels and decreased plasma glucose levels in genetically deficient mice became apparent. Finally, expression pattern of estrogen responsive genes differed in the two experimental models of estrogen deficiency. Both, in uterine and adipose tissues the regulation of expression of some genes either was inversed of regulation or considerably differed in the magnitude of the response in the two models. Our studies demonstrate that the cause of estrogen deficiency significantly impacts on estrogen responsiveness and may be of relevance for investigations on aspects of estrogen deficiency and metabolic and/or menopausal symptoms." @default.
• W2013607445 created "2016-06-24" @default.
• W2013607445 creator A5002263981 @default.
• W2013607445 creator A5010990521 @default.
• W2013607445 creator A5024279250 @default.
• W2013607445 creator A5073307786 @default.
• W2013607445 creator A5089512855 @default.
• W2013607445 date "2011-11-01" @default.
• W2013607445 modified "2023-09-25" @default.
• W2013607445 title "Comparative assessment of estrogenic responses with relevance to the metabolic syndrome and to menopausal symptoms in wild-type and aromatase-knockout mice" @default.
• W2013607445 cites W1546778450 @default.
• W2013607445 cites W1968618595 @default.
• W2013607445 cites W1972943926 @default.
• W2013607445 cites W1979931288 @default.
• W2013607445 cites W1983241347 @default.
• W2013607445 cites W2024934287 @default.
• W2013607445 cites W2038675572 @default.
• W2013607445 cites W2044310473 @default.
• W2013607445 cites W2054700953 @default.
• W2013607445 cites W2070282026 @default.
• W2013607445 cites W2076557594 @default.
• W2013607445 cites W2087955261 @default.
• W2013607445 cites W2093076064 @default.
• W2013607445 cites W2097278525 @default.
• W2013607445 cites W2106395552 @default.
• W2013607445 cites W2118723360 @default.
• W2013607445 cites W2124561896 @default.
• W2013607445 cites W2128242453 @default.
• W2013607445 cites W2132339865 @default.
• W2013607445 cites W2146007589 @default.
• W2013607445 cites W2156234596 @default.
• W2013607445 cites W2156831368 @default.
• W2013607445 cites W2169698990 @default.
• W2013607445 cites W2395168594 @default.
• W2013607445 cites W4248453414 @default.
• W2013607445 doi "https://doi.org/10.1016/j.jsbmb.2011.05.004" @default.
• W2013607445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21621614" @default.
• W2013607445 hasPublicationYear "2011" @default.
• W2013607445 type Work @default.
• W2013607445 sameAs 2013607445 @default.
• W2013607445 citedByCount "7" @default.
• W2013607445 countsByYear W20136074452012 @default.
• W2013607445 countsByYear W20136074452013 @default.
• W2013607445 countsByYear W20136074452014 @default.
• W2013607445 countsByYear W20136074452020 @default.
• W2013607445 crossrefType "journal-article" @default.
• W2013607445 hasAuthorship W2013607445A5002263981 @default.
• W2013607445 hasAuthorship W2013607445A5010990521 @default.
• W2013607445 hasAuthorship W2013607445A5024279250 @default.
• W2013607445 hasAuthorship W2013607445A5073307786 @default.
• W2013607445 hasAuthorship W2013607445A5089512855 @default.
• W2013607445 hasConcept C121608353 @default.
• W2013607445 hasConcept C126322002 @default.
• W2013607445 hasConcept C134018914 @default.
• W2013607445 hasConcept C170493617 @default.
• W2013607445 hasConcept C171089720 @default.
• W2013607445 hasConcept C182704531 @default.
• W2013607445 hasConcept C2776166826 @default.
• W2013607445 hasConcept C2777164284 @default.
• W2013607445 hasConcept C2780613262 @default.
• W2013607445 hasConcept C511355011 @default.
• W2013607445 hasConcept C530470458 @default.
• W2013607445 hasConcept C71924100 @default.
• W2013607445 hasConcept C8264082 @default.
• W2013607445 hasConcept C86803240 @default.
• W2013607445 hasConceptScore W2013607445C121608353 @default.
• W2013607445 hasConceptScore W2013607445C126322002 @default.
• W2013607445 hasConceptScore W2013607445C134018914 @default.
• W2013607445 hasConceptScore W2013607445C170493617 @default.
• W2013607445 hasConceptScore W2013607445C171089720 @default.
• W2013607445 hasConceptScore W2013607445C182704531 @default.
• W2013607445 hasConceptScore W2013607445C2776166826 @default.
• W2013607445 hasConceptScore W2013607445C2777164284 @default.
• W2013607445 hasConceptScore W2013607445C2780613262 @default.
• W2013607445 hasConceptScore W2013607445C511355011 @default.
• W2013607445 hasConceptScore W2013607445C530470458 @default.
• W2013607445 hasConceptScore W2013607445C71924100 @default.
• W2013607445 hasConceptScore W2013607445C8264082 @default.
• W2013607445 hasConceptScore W2013607445C86803240 @default.
• W2013607445 hasLocation W20136074451 @default.
• W2013607445 hasLocation W20136074452 @default.
• W2013607445 hasOpenAccess W2013607445 @default.
• W2013607445 hasPrimaryLocation W20136074451 @default.
• W2013607445 hasRelatedWork W1483224632 @default.
• W2013607445 hasRelatedWork W1572243376 @default.
• W2013607445 hasRelatedWork W1576030095 @default.
• W2013607445 hasRelatedWork W1715115490 @default.
• W2013607445 hasRelatedWork W1979931288 @default.
• W2013607445 hasRelatedWork W2016235551 @default.
• W2013607445 hasRelatedWork W2039102573 @default.
• W2013607445 hasRelatedWork W2045752787 @default.
• W2013607445 hasRelatedWork W2046009739 @default.
• W2013607445 hasRelatedWork W2065452466 @default.
• W2013607445 hasRelatedWork W2075939953 @default.
• W2013607445 hasRelatedWork W2095134324 @default.
• W2013607445 hasRelatedWork W2128242453 @default.
• W2013607445 hasRelatedWork W2136672074 @default.
• W2013607445 hasRelatedWork W2409966011 @default.
• W2013607445 hasRelatedWork W2601474923 @default.
• W2013607445 hasRelatedWork W2988798507 @default.

• next