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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013608841> ?p ?o ?g. }

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• W2013608841 abstract "Enamel development requires the strictly regulated spatiotemporal expression of genes encoding enamel matrix proteins. The mechanisms orchestrating the initiation and termination of gene transcription at each specific stage of amelogenesis are unknown. In this study, we identify <i>cis</i>- regulatory regions necessary for normal enamelin <i>(Enam)</i> expression. Sequence analysis of the <i>Enam</i> promoter 5′-noncoding region identified potentially important <i>cis</i>-regulatory elements located within 5.2 kb upstream of the <i>Enam</i> translation initiation site. DNA constructs containing 5.2 or 3.9 kb upstream of the <i>Enam</i> translation initiation site were linked to an LacZ reporter gene and used to generate transgenic mice. The 3.9-kb <i>Enam</i>-LacZ transgenic lines showed no expression in ameloblasts, but ectopic LacZ staining was detected in osteoblasts. In contrast, the 5.2-kb <i>Enam</i>-LacZ construct was sufficient to mimic the endogenous <i>Enam </i>ameloblast-specific expression pattern. Our study provides new insights into the molecular control of <i>Enam</i> cell- and stage-specific expression." @default.
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• W2013608841 date "2008-08-15" @default.
• W2013608841 modified "2023-10-16" @default.
• W2013608841 title "Identifying Promoter Elements Necessary for Enamelin Tissue-Specific Expression" @default.
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• W2013608841 doi "https://doi.org/10.1159/000151429" @default.
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