Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013609330> ?p ?o ?g. }
- W2013609330 endingPage "1232" @default.
- W2013609330 startingPage "1219" @default.
- W2013609330 abstract "A penetrating traumatic brain injury (pTBI) occurs when an object impacts the head with sufficient force to penetrate the skin, skull, and meninges, and inflict injury directly to the brain parenchyma. This type of injury has been notoriously difficult to model in small laboratory animals such as rats or mice. To this end, we have established a novel non-fatal model for pTBI based on a modified air rifle that accelerates a pellet, which in turn impacts a small probe that then causes the injury to the experimental animal's brain. In the present study, we have focused on the acute phase and characterized the tissue destruction, including increasing cavity formation, white matter degeneration, hemorrhage, edema, and gliosis. We also used a battery of behavioral models to examine the neurological outcome, with the most noteworthy finding being impairment of reference memory function. In conclusion, we have described a number of events taking place after pTBI in our model. We expect this model will prove useful in our efforts to unravel the biological events underlying injury and regeneration after pTBI and possibly serve as a useful animal model in the development of novel therapeutic and diagnostic approaches." @default.
- W2013609330 created "2016-06-24" @default.
- W2013609330 creator A5001823392 @default.
- W2013609330 creator A5008805364 @default.
- W2013609330 creator A5012798032 @default.
- W2013609330 creator A5032198372 @default.
- W2013609330 creator A5065459197 @default.
- W2013609330 date "2012-04-10" @default.
- W2013609330 modified "2023-10-01" @default.
- W2013609330 title "Characterization of a Novel Rat Model of Penetrating Traumatic Brain Injury" @default.
- W2013609330 cites W1495656315 @default.
- W2013609330 cites W1541402103 @default.
- W2013609330 cites W1760881456 @default.
- W2013609330 cites W1852861348 @default.
- W2013609330 cites W1964856373 @default.
- W2013609330 cites W1965493535 @default.
- W2013609330 cites W1969619562 @default.
- W2013609330 cites W1970917906 @default.
- W2013609330 cites W1972753388 @default.
- W2013609330 cites W1973719910 @default.
- W2013609330 cites W1974318434 @default.
- W2013609330 cites W1975198957 @default.
- W2013609330 cites W1975824095 @default.
- W2013609330 cites W1976839120 @default.
- W2013609330 cites W1980011499 @default.
- W2013609330 cites W1980837729 @default.
- W2013609330 cites W1984305500 @default.
- W2013609330 cites W1994049385 @default.
- W2013609330 cites W1996003447 @default.
- W2013609330 cites W1997472471 @default.
- W2013609330 cites W2000760680 @default.
- W2013609330 cites W2001923010 @default.
- W2013609330 cites W2002947389 @default.
- W2013609330 cites W2003890250 @default.
- W2013609330 cites W2006289803 @default.
- W2013609330 cites W2006437073 @default.
- W2013609330 cites W2014457069 @default.
- W2013609330 cites W2015656291 @default.
- W2013609330 cites W2016650346 @default.
- W2013609330 cites W2018973481 @default.
- W2013609330 cites W2019823314 @default.
- W2013609330 cites W2022834577 @default.
- W2013609330 cites W2027340281 @default.
- W2013609330 cites W2034358253 @default.
- W2013609330 cites W2041860929 @default.
- W2013609330 cites W2042940424 @default.
- W2013609330 cites W2049173294 @default.
- W2013609330 cites W2051961329 @default.
- W2013609330 cites W2056804957 @default.
- W2013609330 cites W2058035812 @default.
- W2013609330 cites W2058329822 @default.
- W2013609330 cites W2062524407 @default.
- W2013609330 cites W2063570824 @default.
- W2013609330 cites W2065071078 @default.
- W2013609330 cites W2067629356 @default.
- W2013609330 cites W2074661552 @default.
- W2013609330 cites W2076554399 @default.
- W2013609330 cites W2076948553 @default.
- W2013609330 cites W2079624058 @default.
- W2013609330 cites W2079730704 @default.
- W2013609330 cites W2080069940 @default.
- W2013609330 cites W2081504325 @default.
- W2013609330 cites W2083267292 @default.
- W2013609330 cites W2086320583 @default.
- W2013609330 cites W2090592748 @default.
- W2013609330 cites W2098161981 @default.
- W2013609330 cites W2103044571 @default.
- W2013609330 cites W2107464534 @default.
- W2013609330 cites W2125665709 @default.
- W2013609330 cites W2128744963 @default.
- W2013609330 cites W2128751464 @default.
- W2013609330 cites W2139856187 @default.
- W2013609330 cites W2142424019 @default.
- W2013609330 cites W2148898943 @default.
- W2013609330 cites W2150800185 @default.
- W2013609330 cites W2151028682 @default.
- W2013609330 cites W2165776322 @default.
- W2013609330 cites W2166376912 @default.
- W2013609330 cites W2169289420 @default.
- W2013609330 cites W2913002770 @default.
- W2013609330 cites W4210981518 @default.
- W2013609330 doi "https://doi.org/10.1089/neu.2011.2182" @default.
- W2013609330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22181060" @default.
- W2013609330 hasPublicationYear "2012" @default.
- W2013609330 type Work @default.
- W2013609330 sameAs 2013609330 @default.
- W2013609330 citedByCount "51" @default.
- W2013609330 countsByYear W20136093302012 @default.
- W2013609330 countsByYear W20136093302013 @default.
- W2013609330 countsByYear W20136093302014 @default.
- W2013609330 countsByYear W20136093302015 @default.
- W2013609330 countsByYear W20136093302016 @default.
- W2013609330 countsByYear W20136093302017 @default.
- W2013609330 countsByYear W20136093302019 @default.
- W2013609330 countsByYear W20136093302020 @default.
- W2013609330 countsByYear W20136093302021 @default.
- W2013609330 countsByYear W20136093302022 @default.
- W2013609330 countsByYear W20136093302023 @default.