FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013609600> ?p ?o ?g. }

• W2013609600 endingPage "e17286" @default.
• W2013609600 startingPage "e17286" @default.
• W2013609600 abstract "The development of the mammalian kidney is well conserved from mouse to man. Despite considerable temporal and spatial data on gene expression in mammalian kidney development, primarily in rodent species, there is a paucity of genes whose expression is absolutely specific to a given anatomical compartment and/or developmental stage, defined here as 'anchor' genes. We previously generated an atlas of gene expression in the developing mouse kidney using microarray analysis of anatomical compartments collected via laser capture microdissection. Here, this data is further analysed to identify anchor genes via stringent bioinformatic filtering followed by high resolution section in situ hybridisation performed on 200 transcripts selected as specific to one of 11 anatomical compartments within the midgestation mouse kidney. A total of 37 anchor genes were identified across 6 compartments with the early proximal tubule being the compartment richest in anchor genes. Analysis of minimal and evolutionarily conserved promoter regions of this set of 25 anchor genes identified enrichment of transcription factor binding sites for Hnf4a and Hnf1b, RbpJ (Notch signalling), PPARγ:RxRA and COUP-TF family transcription factors. This was reinforced by GO analyses which also identified these anchor genes as targets in processes including epithelial proliferation and proximal tubular function. As well as defining anchor genes, this large scale validation of gene expression identified a further 92 compartment-enriched genes able to subcompartmentalise key processes during murine renal organogenesis spatially or ontologically. This included a cohort of 13 ureteric epithelial genes revealing previously unappreciated compartmentalisation of the collecting duct system and a series of early tubule genes suggesting that segmentation into proximal tubule, loop of Henle and distal tubule does not occur until the onset of glomerular vascularisation. Overall, this study serves to illuminate previously ill-defined stages of patterning and will enable further refinement of the lineage relationships within mammalian kidney development." @default.
• W2013609600 created "2016-06-24" @default.
• W2013609600 creator A5004895766 @default.
• W2013609600 creator A5005438786 @default.
• W2013609600 creator A5023041111 @default.
• W2013609600 creator A5026506282 @default.
• W2013609600 creator A5040120471 @default.
• W2013609600 creator A5059752349 @default.
• W2013609600 creator A5064293072 @default.
• W2013609600 creator A5065614495 @default.
• W2013609600 creator A5086735487 @default.
• W2013609600 date "2011-02-28" @default.
• W2013609600 modified "2023-10-14" @default.
• W2013609600 title "Identification of Anchor Genes during Kidney Development Defines Ontological Relationships, Molecular Subcompartments and Regulatory Pathways" @default.
• W2013609600 cites W168257375 @default.
• W2013609600 cites W1967071130 @default.
• W2013609600 cites W1970062316 @default.
• W2013609600 cites W1971689970 @default.
• W2013609600 cites W1974939794 @default.
• W2013609600 cites W1977466966 @default.
• W2013609600 cites W1979659675 @default.
• W2013609600 cites W1980020302 @default.
• W2013609600 cites W1981735567 @default.
• W2013609600 cites W1982103636 @default.
• W2013609600 cites W1987874305 @default.
• W2013609600 cites W1991560559 @default.
• W2013609600 cites W1999089403 @default.
• W2013609600 cites W2000334616 @default.
• W2013609600 cites W2010261215 @default.
• W2013609600 cites W2010280514 @default.
• W2013609600 cites W2011143322 @default.
• W2013609600 cites W2013614705 @default.
• W2013609600 cites W2014784548 @default.
• W2013609600 cites W2016732271 @default.
• W2013609600 cites W2018091219 @default.
• W2013609600 cites W2018701070 @default.
• W2013609600 cites W2028810156 @default.
• W2013609600 cites W2029229719 @default.
• W2013609600 cites W2029535420 @default.
• W2013609600 cites W2042250402 @default.
• W2013609600 cites W2044118402 @default.
• W2013609600 cites W2045042588 @default.
• W2013609600 cites W2046518908 @default.
• W2013609600 cites W2048136172 @default.
• W2013609600 cites W2066484100 @default.
• W2013609600 cites W2071721087 @default.
• W2013609600 cites W2072106614 @default.
• W2013609600 cites W2073641804 @default.
• W2013609600 cites W2082556692 @default.
• W2013609600 cites W2082689543 @default.
• W2013609600 cites W2084585178 @default.
• W2013609600 cites W2084620487 @default.
• W2013609600 cites W2093651222 @default.
• W2013609600 cites W2094059784 @default.
• W2013609600 cites W2099296620 @default.
• W2013609600 cites W2121616521 @default.
• W2013609600 cites W2123490534 @default.
• W2013609600 cites W2123491442 @default.
• W2013609600 cites W2127031542 @default.
• W2013609600 cites W2135750955 @default.
• W2013609600 cites W2140551998 @default.
• W2013609600 cites W2143508168 @default.
• W2013609600 cites W2144212283 @default.
• W2013609600 cites W2144382808 @default.
• W2013609600 cites W2145111609 @default.
• W2013609600 cites W2146445411 @default.
• W2013609600 cites W2150772401 @default.
• W2013609600 cites W2160810865 @default.
• W2013609600 cites W2164192503 @default.
• W2013609600 cites W2206997096 @default.
• W2013609600 doi "https://doi.org/10.1371/journal.pone.0017286" @default.
• W2013609600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3046260" @default.
• W2013609600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21386911" @default.
• W2013609600 hasPublicationYear "2011" @default.
• W2013609600 type Work @default.
• W2013609600 sameAs 2013609600 @default.
• W2013609600 citedByCount "76" @default.
• W2013609600 countsByYear W20136096002012 @default.
• W2013609600 countsByYear W20136096002013 @default.
• W2013609600 countsByYear W20136096002014 @default.
• W2013609600 countsByYear W20136096002015 @default.
• W2013609600 countsByYear W20136096002016 @default.
• W2013609600 countsByYear W20136096002017 @default.
• W2013609600 countsByYear W20136096002018 @default.
• W2013609600 countsByYear W20136096002019 @default.
• W2013609600 countsByYear W20136096002020 @default.
• W2013609600 countsByYear W20136096002021 @default.
• W2013609600 countsByYear W20136096002022 @default.
• W2013609600 countsByYear W20136096002023 @default.
• W2013609600 crossrefType "journal-article" @default.
• W2013609600 hasAuthorship W2013609600A5004895766 @default.
• W2013609600 hasAuthorship W2013609600A5005438786 @default.
• W2013609600 hasAuthorship W2013609600A5023041111 @default.
• W2013609600 hasAuthorship W2013609600A5026506282 @default.
• W2013609600 hasAuthorship W2013609600A5040120471 @default.
• W2013609600 hasAuthorship W2013609600A5059752349 @default.
• W2013609600 hasAuthorship W2013609600A5064293072 @default.
• W2013609600 hasAuthorship W2013609600A5065614495 @default.

• next