FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013609993> ?p ?o ?g. }

• W2013609993 endingPage "e39655" @default.
• W2013609993 startingPage "e39655" @default.
• W2013609993 abstract "Numerous studies have yielded inconclusive results regarding the relationship between tumor suppressor protein TP53 overexpression and/or TP53 gene mutations and the response to neoadjuvant chemotherapy in patients with breast cancer. The purpose of the current study was therefore to evaluate the relationship between TP53 status and response to chemotherapy in breast cancer.A total of 26 previously published eligible studies including 3,476 cases were identified and included in this meta-analysis. TP53 status (over expression of TP53 protein and/or TP53 gene mutations) was associated with good response in breast cancer patients who received neoadjuvant chemotherapy (total objective response: risk ratio [RR]= 1.20, 95% confidence interval [CI]= 1.09-1.33, p<0.001; pathological objective response: RR = 1.37, 95% CI = 1.20-1.57, p<0.01; total complete response: RR = 1.33, 95% CI = 1.15-1.53, p<0.001; pathological complete response: RR = 1.45, 95% CI = 1.25-1.68, p<0.001). In further stratified analyses, this association also existed among the studies using anthracycline-based neoadjuvant chemotherapy, and the association between response and the presence of gene alterations was stronger than that between response and immunohistochemistry positivity.The results of the present meta-analysis suggest that TP53 status is a predictive factor for response in breast cancer patients undergoing neoadjuvant chemotherapy. Further larger and well-designed prospective studies are required to evaluate the predictive role of TP53 status in clinical practice." @default.
• W2013609993 created "2016-06-24" @default.
• W2013609993 creator A5026782331 @default.
• W2013609993 creator A5044285390 @default.
• W2013609993 creator A5050701259 @default.
• W2013609993 creator A5068066953 @default.
• W2013609993 creator A5070200464 @default.
• W2013609993 creator A5074387878 @default.
• W2013609993 creator A5091127842 @default.
• W2013609993 date "2012-06-29" @default.
• W2013609993 modified "2023-09-26" @default.
• W2013609993 title "Value of TP53 Status for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer: A Meta-Analysis" @default.
• W2013609993 cites W1970210435 @default.
• W2013609993 cites W1974135529 @default.
• W2013609993 cites W1977131634 @default.
• W2013609993 cites W1979319210 @default.
• W2013609993 cites W1989465474 @default.
• W2013609993 cites W1996813392 @default.
• W2013609993 cites W2003029412 @default.
• W2013609993 cites W2013282919 @default.
• W2013609993 cites W2041321380 @default.
• W2013609993 cites W2048295112 @default.
• W2013609993 cites W2059267214 @default.
• W2013609993 cites W2066882336 @default.
• W2013609993 cites W2075621065 @default.
• W2013609993 cites W2076227688 @default.
• W2013609993 cites W2081894694 @default.
• W2013609993 cites W2082462313 @default.
• W2013609993 cites W2091205535 @default.
• W2013609993 cites W2112778582 @default.
• W2013609993 cites W2117550296 @default.
• W2013609993 cites W2118097861 @default.
• W2013609993 cites W2130763408 @default.
• W2013609993 cites W2133959309 @default.
• W2013609993 cites W2139248078 @default.
• W2013609993 cites W213957447 @default.
• W2013609993 cites W2142486051 @default.
• W2013609993 cites W2165608465 @default.
• W2013609993 cites W2165980159 @default.
• W2013609993 cites W2167805334 @default.
• W2013609993 cites W2167926320 @default.
• W2013609993 doi "https://doi.org/10.1371/journal.pone.0039655" @default.
• W2013609993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3387248" @default.
• W2013609993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22768103" @default.
• W2013609993 hasPublicationYear "2012" @default.
• W2013609993 type Work @default.
• W2013609993 sameAs 2013609993 @default.
• W2013609993 citedByCount "30" @default.
• W2013609993 countsByYear W20136099932014 @default.
• W2013609993 countsByYear W20136099932015 @default.
• W2013609993 countsByYear W20136099932016 @default.
• W2013609993 countsByYear W20136099932017 @default.
• W2013609993 countsByYear W20136099932018 @default.
• W2013609993 countsByYear W20136099932019 @default.
• W2013609993 countsByYear W20136099932020 @default.
• W2013609993 countsByYear W20136099932021 @default.
• W2013609993 countsByYear W20136099932022 @default.
• W2013609993 countsByYear W20136099932023 @default.
• W2013609993 crossrefType "journal-article" @default.
• W2013609993 hasAuthorship W2013609993A5026782331 @default.
• W2013609993 hasAuthorship W2013609993A5044285390 @default.
• W2013609993 hasAuthorship W2013609993A5050701259 @default.
• W2013609993 hasAuthorship W2013609993A5068066953 @default.
• W2013609993 hasAuthorship W2013609993A5070200464 @default.
• W2013609993 hasAuthorship W2013609993A5074387878 @default.
• W2013609993 hasAuthorship W2013609993A5091127842 @default.
• W2013609993 hasBestOaLocation W20136099931 @default.
• W2013609993 hasConcept C121608353 @default.
• W2013609993 hasConcept C126322002 @default.
• W2013609993 hasConcept C143998085 @default.
• W2013609993 hasConcept C2776694085 @default.
• W2013609993 hasConcept C2776802502 @default.
• W2013609993 hasConcept C2778292576 @default.
• W2013609993 hasConcept C2780521871 @default.
• W2013609993 hasConcept C44249647 @default.
• W2013609993 hasConcept C530470458 @default.
• W2013609993 hasConcept C71924100 @default.
• W2013609993 hasConcept C95190672 @default.
• W2013609993 hasConceptScore W2013609993C121608353 @default.
• W2013609993 hasConceptScore W2013609993C126322002 @default.
• W2013609993 hasConceptScore W2013609993C143998085 @default.
• W2013609993 hasConceptScore W2013609993C2776694085 @default.
• W2013609993 hasConceptScore W2013609993C2776802502 @default.
• W2013609993 hasConceptScore W2013609993C2778292576 @default.
• W2013609993 hasConceptScore W2013609993C2780521871 @default.
• W2013609993 hasConceptScore W2013609993C44249647 @default.
• W2013609993 hasConceptScore W2013609993C530470458 @default.
• W2013609993 hasConceptScore W2013609993C71924100 @default.
• W2013609993 hasConceptScore W2013609993C95190672 @default.
• W2013609993 hasIssue "6" @default.
• W2013609993 hasLocation W20136099931 @default.
• W2013609993 hasLocation W20136099932 @default.
• W2013609993 hasLocation W20136099933 @default.
• W2013609993 hasLocation W20136099934 @default.
• W2013609993 hasOpenAccess W2013609993 @default.
• W2013609993 hasPrimaryLocation W20136099931 @default.
• W2013609993 hasRelatedWork W1810920307 @default.
• W2013609993 hasRelatedWork W2013609993 @default.

• next