Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013612418> ?p ?o ?g. }
- W2013612418 endingPage "CMO.S4259" @default.
- W2013612418 startingPage "CMO.S4259" @default.
- W2013612418 abstract "Just over a decade ago, gastrointestinal tumours were a poorly understood mesenchymal neoplasm unsuccessfully treated with chemotherapy. Cytotoxic therapy for advanced disease yielded response rates of 10% and median survival of just 18 months. However, the discovery of KIT and platelet derived growth factor receptor alpha ( PDGFRA) mutations as oncogenic drivers of most gastrointestinal tumours, paved the way for targeted therapy. Imatinib mesylate, a tyrosine kinase inhibitor, produces a clinical benefit rate (complete response, partial response, and stable disease) of more than 80% in metastatic setting and a median survival of 57 months. Imatinib is now also approved in adult patients following resection of KIT-positive GIST. Major insights into the mechanism of action of imatinib, unique pharmacokinetics, drug resistance, and management of low grade but chronic adverse effects continue to be made." @default.
- W2013612418 created "2016-06-24" @default.
- W2013612418 creator A5070495365 @default.
- W2013612418 date "2011-01-01" @default.
- W2013612418 modified "2023-09-26" @default.
- W2013612418 title "Imatinib Mesylate: Past Successes and Future Challenges in the Treatment of Gastrointestinal Stromal Tumors" @default.
- W2013612418 cites W1860834355 @default.
- W2013612418 cites W1967486963 @default.
- W2013612418 cites W1967773734 @default.
- W2013612418 cites W1972972704 @default.
- W2013612418 cites W1981491302 @default.
- W2013612418 cites W1992781063 @default.
- W2013612418 cites W1995930366 @default.
- W2013612418 cites W1998990808 @default.
- W2013612418 cites W1999106017 @default.
- W2013612418 cites W2004789146 @default.
- W2013612418 cites W2008920989 @default.
- W2013612418 cites W2012978969 @default.
- W2013612418 cites W2013837038 @default.
- W2013612418 cites W2014183075 @default.
- W2013612418 cites W2016576372 @default.
- W2013612418 cites W2018726802 @default.
- W2013612418 cites W2028959752 @default.
- W2013612418 cites W2034074778 @default.
- W2013612418 cites W2049103239 @default.
- W2013612418 cites W2050894854 @default.
- W2013612418 cites W2055436404 @default.
- W2013612418 cites W2056139735 @default.
- W2013612418 cites W2057265838 @default.
- W2013612418 cites W2057319282 @default.
- W2013612418 cites W2062428732 @default.
- W2013612418 cites W2064308866 @default.
- W2013612418 cites W2068079378 @default.
- W2013612418 cites W2070069754 @default.
- W2013612418 cites W2079420659 @default.
- W2013612418 cites W2079503326 @default.
- W2013612418 cites W2083954708 @default.
- W2013612418 cites W2088513788 @default.
- W2013612418 cites W2102769930 @default.
- W2013612418 cites W2103304755 @default.
- W2013612418 cites W2104899243 @default.
- W2013612418 cites W2107464631 @default.
- W2013612418 cites W2115504770 @default.
- W2013612418 cites W2115811601 @default.
- W2013612418 cites W2117016337 @default.
- W2013612418 cites W2123346471 @default.
- W2013612418 cites W2124524221 @default.
- W2013612418 cites W2125317841 @default.
- W2013612418 cites W2126042521 @default.
- W2013612418 cites W2128518955 @default.
- W2013612418 cites W2128942433 @default.
- W2013612418 cites W2129093214 @default.
- W2013612418 cites W2129931005 @default.
- W2013612418 cites W2134094496 @default.
- W2013612418 cites W2139511378 @default.
- W2013612418 cites W2149330162 @default.
- W2013612418 cites W2150501295 @default.
- W2013612418 cites W2154169171 @default.
- W2013612418 cites W2160314349 @default.
- W2013612418 cites W2160926199 @default.
- W2013612418 cites W2165837347 @default.
- W2013612418 cites W2166595100 @default.
- W2013612418 cites W2167112360 @default.
- W2013612418 cites W2169348844 @default.
- W2013612418 cites W2169363650 @default.
- W2013612418 cites W2171620774 @default.
- W2013612418 cites W2199227036 @default.
- W2013612418 cites W2314511842 @default.
- W2013612418 cites W2324850882 @default.
- W2013612418 cites W2337039075 @default.
- W2013612418 cites W2505276486 @default.
- W2013612418 cites W4210379128 @default.
- W2013612418 cites W4231544410 @default.
- W2013612418 cites W4235712850 @default.
- W2013612418 cites W4237238628 @default.
- W2013612418 cites W4238208852 @default.
- W2013612418 cites W4248586401 @default.
- W2013612418 doi "https://doi.org/10.4137/cmo.s4259" @default.
- W2013612418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3235999" @default.
- W2013612418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22174597" @default.
- W2013612418 hasPublicationYear "2011" @default.
- W2013612418 type Work @default.
- W2013612418 sameAs 2013612418 @default.
- W2013612418 citedByCount "15" @default.
- W2013612418 countsByYear W20136124182012 @default.
- W2013612418 countsByYear W20136124182013 @default.
- W2013612418 countsByYear W20136124182014 @default.
- W2013612418 countsByYear W20136124182015 @default.
- W2013612418 countsByYear W20136124182016 @default.
- W2013612418 countsByYear W20136124182018 @default.
- W2013612418 countsByYear W20136124182019 @default.
- W2013612418 countsByYear W20136124182020 @default.
- W2013612418 countsByYear W20136124182023 @default.
- W2013612418 crossrefType "journal-article" @default.
- W2013612418 hasAuthorship W2013612418A5070495365 @default.
- W2013612418 hasBestOaLocation W20136124181 @default.
- W2013612418 hasConcept C121608353 @default.
- W2013612418 hasConcept C126322002 @default.