FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013619393> ?p ?o ?g. }

• W2013619393 endingPage "e0003659" @default.
• W2013619393 startingPage "e0003659" @default.
• W2013619393 abstract "Background Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8+ T-cell abnormalities and CD8-enriched myocarditis occurring in an inflammatory milieu. Pentoxifylline (PTX), a phosphodiesterase inhibitor, has immunoregulatory and cardioprotective properties. Here, we tested PTX effects on CD8+ T-cell abnormalities and cardiac alterations using a model of experimental Chagas’ heart disease. Methodology/Principal Findings C57BL/6 mice chronically infected by the Colombian Trypanosoma cruzi strain and presenting signs of CCC were treated with PTX. The downmodulation of T-cell receptors on CD8+ cells induced by T. cruzi infection was rescued by PTX therapy. Also, PTX reduced the frequency of CD8+ T-cells expressing activation and migration markers in the spleen and the activation of blood vessel endothelial cells and the intensity of inflammation in the heart tissue. Although preserved interferon-gamma production systemically and in the cardiac tissue, PTX therapy reduced the number of perforin+ cells invading this tissue. PTX did not alter parasite load, but hampered the progression of heart injury, improving connexin 43 expression and decreasing fibronectin overdeposition. Further, PTX reversed electrical abnormalities as bradycardia and prolonged PR, QTc and QRS intervals in chronically infected mice. Moreover, PTX therapy improved heart remodeling since reduced left ventricular (LV) hypertrophy and restored the decreased LV ejection fraction. Conclusions/Significance PTX therapy ameliorates critical aspects of CCC and repositioned CD8+ T-cell response towards homeostasis, reinforcing that immunological abnormalities are crucially linked, as cause or effect, to CCC. Therefore, PTX emerges as a candidate to treat the non-beneficial immune deregulation associated with chronic Chagas' heart disease and to improve prognosis." @default.
• W2013619393 created "2016-06-24" @default.
• W2013619393 creator A5020546900 @default.
• W2013619393 creator A5043529938 @default.
• W2013619393 creator A5056224162 @default.
• W2013619393 creator A5058488038 @default.
• W2013619393 creator A5061734746 @default.
• W2013619393 creator A5068505786 @default.
• W2013619393 creator A5070096680 @default.
• W2013619393 creator A5076343777 @default.
• W2013619393 date "2015-03-19" @default.
• W2013619393 modified "2023-09-25" @default.
• W2013619393 title "Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8+ T-Cell Response" @default.
• W2013619393 cites W1510345740 @default.
• W2013619393 cites W1600560134 @default.
• W2013619393 cites W1631250427 @default.
• W2013619393 cites W1896845502 @default.
• W2013619393 cites W1934185378 @default.
• W2013619393 cites W1951798749 @default.
• W2013619393 cites W1961392756 @default.
• W2013619393 cites W1967961046 @default.
• W2013619393 cites W1968350998 @default.
• W2013619393 cites W1971853331 @default.
• W2013619393 cites W1972209585 @default.
• W2013619393 cites W1978220640 @default.
• W2013619393 cites W1979905466 @default.
• W2013619393 cites W1981480494 @default.
• W2013619393 cites W1985612204 @default.
• W2013619393 cites W1990863238 @default.
• W2013619393 cites W1994316495 @default.
• W2013619393 cites W1994476817 @default.
• W2013619393 cites W1996959393 @default.
• W2013619393 cites W1999015670 @default.
• W2013619393 cites W2000742409 @default.
• W2013619393 cites W2009376183 @default.
• W2013619393 cites W2009825966 @default.
• W2013619393 cites W2010696369 @default.
• W2013619393 cites W2015983369 @default.
• W2013619393 cites W2020942857 @default.
• W2013619393 cites W2027068762 @default.
• W2013619393 cites W2031278032 @default.
• W2013619393 cites W2035809865 @default.
• W2013619393 cites W2042454446 @default.
• W2013619393 cites W2046733260 @default.
• W2013619393 cites W2047184918 @default.
• W2013619393 cites W2050797696 @default.
• W2013619393 cites W2051283137 @default.
• W2013619393 cites W2053616313 @default.
• W2013619393 cites W2056627953 @default.
• W2013619393 cites W2058442887 @default.
• W2013619393 cites W2060617067 @default.
• W2013619393 cites W2061246349 @default.
• W2013619393 cites W2063311461 @default.
• W2013619393 cites W2064216140 @default.
• W2013619393 cites W2072445418 @default.
• W2013619393 cites W2073078616 @default.
• W2013619393 cites W2073469002 @default.
• W2013619393 cites W2073501462 @default.
• W2013619393 cites W2089115976 @default.
• W2013619393 cites W2091651330 @default.
• W2013619393 cites W2094835614 @default.
• W2013619393 cites W2106687915 @default.
• W2013619393 cites W2107277218 @default.
• W2013619393 cites W2112356007 @default.
• W2013619393 cites W2114516903 @default.
• W2013619393 cites W2118673294 @default.
• W2013619393 cites W2119739580 @default.
• W2013619393 cites W2129660718 @default.
• W2013619393 cites W2130253859 @default.
• W2013619393 cites W2134566372 @default.
• W2013619393 cites W2135039623 @default.
• W2013619393 cites W2138018919 @default.
• W2013619393 cites W2144047873 @default.
• W2013619393 cites W2146279195 @default.
• W2013619393 cites W2151848444 @default.
• W2013619393 cites W2153960708 @default.
• W2013619393 cites W2192080449 @default.
• W2013619393 cites W2413727084 @default.
• W2013619393 cites W2417396513 @default.
• W2013619393 cites W2429845057 @default.
• W2013619393 cites W4210980497 @default.
• W2013619393 doi "https://doi.org/10.1371/journal.pntd.0003659" @default.
• W2013619393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4366205" @default.
• W2013619393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25789471" @default.
• W2013619393 hasPublicationYear "2015" @default.
• W2013619393 type Work @default.
• W2013619393 sameAs 2013619393 @default.
• W2013619393 citedByCount "29" @default.
• W2013619393 countsByYear W20136193932015 @default.
• W2013619393 countsByYear W20136193932016 @default.
• W2013619393 countsByYear W20136193932017 @default.
• W2013619393 countsByYear W20136193932018 @default.
• W2013619393 countsByYear W20136193932019 @default.
• W2013619393 countsByYear W20136193932020 @default.
• W2013619393 countsByYear W20136193932021 @default.
• W2013619393 countsByYear W20136193932022 @default.
• W2013619393 countsByYear W20136193932023 @default.
• W2013619393 crossrefType "journal-article" @default.

• next