FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013630786> ?p ?o ?g. }

• W2013630786 endingPage "40" @default.
• W2013630786 startingPage "33" @default.
• W2013630786 abstract "The anti-atherogenic properties of human apoprotein E-associated lipoproteins have been partially attributed to its anti-inflammatory properties. We studied if endogenously expressed apoprotein E (apoE) elicits isoform-dependent effects on pro-inflammatory cytokine expression and secretion. Mouse J774A.1 peritoneal macrophages without native expression of apoE were used to establish cell lines with stable expression of the three human apoE isoforms, apoE2, apoE3 and apoE4. In the presence of lipopolysaccharide (LPS), expression and secretion of TNF-α and IL-6 in cells expressing different apoE isoforms were determined by RT-PCR, immunoblotting and ELISA assays. ApoE3-expressing cells have significantly lower expression and secretion levels of the two cytokines as compared to cells with apoE2 and apoE4 expression. Such observations were accompanied with the lowest ERK1/2 activity in apoE3-expressing cells. Further study shows that the apoE isoform-dependent variations of TNF-α and IL-6 expression/secretion in macrophages are diminished in the presence of ERK1/2 inhibitor U0126. In conclusion, apoE elicits isoform-dependent effects on macrophage TNF-α and IL-6 expression as well as secretion. The ERK1/2 signaling pathways are involved in mediating such apoE isoform-dependent effects." @default.
• W2013630786 created "2016-06-24" @default.
• W2013630786 creator A5015578410 @default.
• W2013630786 creator A5036599980 @default.
• W2013630786 creator A5060030240 @default.
• W2013630786 creator A5076402674 @default.
• W2013630786 date "2007-04-01" @default.
• W2013630786 modified "2023-09-26" @default.
• W2013630786 title "Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-α and IL-6 in macrophages" @default.
• W2013630786 cites W1736154854 @default.
• W2013630786 cites W1926521347 @default.
• W2013630786 cites W1969348726 @default.
• W2013630786 cites W1973614704 @default.
• W2013630786 cites W1984736956 @default.
• W2013630786 cites W1997756128 @default.
• W2013630786 cites W2000039441 @default.
• W2013630786 cites W2001580765 @default.
• W2013630786 cites W2012797534 @default.
• W2013630786 cites W2016579573 @default.
• W2013630786 cites W2022398608 @default.
• W2013630786 cites W2029354317 @default.
• W2013630786 cites W2033013849 @default.
• W2013630786 cites W2033365840 @default.
• W2013630786 cites W2033538734 @default.
• W2013630786 cites W2034691653 @default.
• W2013630786 cites W2034968148 @default.
• W2013630786 cites W2041981966 @default.
• W2013630786 cites W2041994724 @default.
• W2013630786 cites W2046445606 @default.
• W2013630786 cites W2046641769 @default.
• W2013630786 cites W2056708102 @default.
• W2013630786 cites W2079517191 @default.
• W2013630786 cites W2086262311 @default.
• W2013630786 cites W2095620419 @default.
• W2013630786 cites W2108404291 @default.
• W2013630786 cites W2114063969 @default.
• W2013630786 cites W2121101037 @default.
• W2013630786 cites W2123153259 @default.
• W2013630786 cites W2128324529 @default.
• W2013630786 cites W2144076105 @default.
• W2013630786 cites W2144373514 @default.
• W2013630786 cites W2153218744 @default.
• W2013630786 cites W2159069239 @default.
• W2013630786 cites W2163394733 @default.
• W2013630786 cites W2164449928 @default.
• W2013630786 cites W2165626477 @default.
• W2013630786 cites W2171096197 @default.
• W2013630786 doi "https://doi.org/10.1016/j.abb.2007.01.019" @default.
• W2013630786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17353005" @default.
• W2013630786 hasPublicationYear "2007" @default.
• W2013630786 type Work @default.
• W2013630786 sameAs 2013630786 @default.
• W2013630786 citedByCount "42" @default.
• W2013630786 countsByYear W20136307862012 @default.
• W2013630786 countsByYear W20136307862013 @default.
• W2013630786 countsByYear W20136307862014 @default.
• W2013630786 countsByYear W20136307862015 @default.
• W2013630786 countsByYear W20136307862016 @default.
• W2013630786 countsByYear W20136307862017 @default.
• W2013630786 countsByYear W20136307862019 @default.
• W2013630786 countsByYear W20136307862020 @default.
• W2013630786 countsByYear W20136307862021 @default.
• W2013630786 countsByYear W20136307862022 @default.
• W2013630786 countsByYear W20136307862023 @default.
• W2013630786 crossrefType "journal-article" @default.
• W2013630786 hasAuthorship W2013630786A5015578410 @default.
• W2013630786 hasAuthorship W2013630786A5036599980 @default.
• W2013630786 hasAuthorship W2013630786A5060030240 @default.
• W2013630786 hasAuthorship W2013630786A5076402674 @default.
• W2013630786 hasConcept C104317684 @default.
• W2013630786 hasConcept C126322002 @default.
• W2013630786 hasConcept C134018914 @default.
• W2013630786 hasConcept C153911025 @default.
• W2013630786 hasConcept C17991360 @default.
• W2013630786 hasConcept C185592680 @default.
• W2013630786 hasConcept C202751555 @default.
• W2013630786 hasConcept C203014093 @default.
• W2013630786 hasConcept C2776914184 @default.
• W2013630786 hasConcept C2778690821 @default.
• W2013630786 hasConcept C2778754761 @default.
• W2013630786 hasConcept C2779134260 @default.
• W2013630786 hasConcept C2779244956 @default.
• W2013630786 hasConcept C49039625 @default.
• W2013630786 hasConcept C53345823 @default.
• W2013630786 hasConcept C55493867 @default.
• W2013630786 hasConcept C57089818 @default.
• W2013630786 hasConcept C71924100 @default.
• W2013630786 hasConcept C86803240 @default.
• W2013630786 hasConcept C95444343 @default.
• W2013630786 hasConceptScore W2013630786C104317684 @default.
• W2013630786 hasConceptScore W2013630786C126322002 @default.
• W2013630786 hasConceptScore W2013630786C134018914 @default.
• W2013630786 hasConceptScore W2013630786C153911025 @default.
• W2013630786 hasConceptScore W2013630786C17991360 @default.
• W2013630786 hasConceptScore W2013630786C185592680 @default.
• W2013630786 hasConceptScore W2013630786C202751555 @default.
• W2013630786 hasConceptScore W2013630786C203014093 @default.
• W2013630786 hasConceptScore W2013630786C2776914184 @default.

• next