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- W2013639487 abstract "Specific therapy for the treatment of human diseases is the desired goal in medicine, and during the past century we have made tremendous progress towards this aim, starting with the discovey and development of antibiotics for use against bacterial agents. The current age of molecular biology has led to a greater understanding of viral replication and gene action, and the ability to manufacture pure proteins through recombinant DNA technology. Simultaneous research in cancer cells has identified proteins (proto- and oncogenes) associated with malignancy growth, cell death, differentiation and replication. The complete sequencing of the human genome now permits us to identify and locate those specific genes associated with various disease states, and gene array assays and proteomics permit the study of relative gene expression. An entire class of new molecular therapeutics is now able to specifically target those genes and regulate their function. Antisense oligonocleotides appear to be the agents of choice for this purpose and many antisense compounds are currently in clinical studies. As in the case of antibacterial and antiviral agents before them, antisense therapeutics are still being optimized in terms of their application and delivery." @default.
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- W2013639487 date "2004-01-01" @default.
- W2013639487 modified "2023-10-17" @default.
- W2013639487 title "A review of antisense oligonucleotides in the treatment of human disease" @default.
- W2013639487 doi "https://doi.org/10.1358/dof.2004.029.09.854176" @default.
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