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• W2013644564 abstract "Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA ( N -methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is “anti-Hebbian”:Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity." @default.
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• W2013644564 date "2007-03-02" @default.
• W2013644564 modified "2023-09-23" @default.
• W2013644564 title "Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit" @default.
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• W2013644564 doi "https://doi.org/10.1126/science.1137450" @default.
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