Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013646237> ?p ?o ?g. }
- W2013646237 endingPage "507" @default.
- W2013646237 startingPage "495" @default.
- W2013646237 abstract "G-quadruplexes are noncanonical structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. Experimental studies and computational predictions show that RNA G-quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts. RNA G-quadruplexes at these specific locations play important roles in key cellular functions, including telomere homeostasis and gene expression. Indeed, RNA G-quadruplexes appear as important regulators of pre-mRNA processing (splicing and polyadenylation), RNA turnover, mRNA targeting and translation. The regulatory mechanisms controlled by RNA G-quadruplexes involve the binding of protein factors that modulate G-quadruplex conformation and/or serve as a bridge to recruit additional protein regulators. In this review, we summarize the current knowledge on the role of G-quadruplexes in RNA biology with particular emphasis on the molecular mechanisms underlying their specific function in RNA metabolism occurring in physiological or pathological conditions. WIREs RNA 2012, 3:495–507. doi: 10.1002/wrna.1113 This article is categorized under: RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications" @default.
- W2013646237 created "2016-06-24" @default.
- W2013646237 creator A5038041116 @default.
- W2013646237 creator A5081632204 @default.
- W2013646237 creator A5091847535 @default.
- W2013646237 date "2012-04-04" @default.
- W2013646237 modified "2023-10-05" @default.
- W2013646237 title "G-quadruplexes in RNA biology" @default.
- W2013646237 cites W1523125680 @default.
- W2013646237 cites W1699609454 @default.
- W2013646237 cites W1810809543 @default.
- W2013646237 cites W1879167427 @default.
- W2013646237 cites W1946213733 @default.
- W2013646237 cites W1964177189 @default.
- W2013646237 cites W1964578544 @default.
- W2013646237 cites W1964680558 @default.
- W2013646237 cites W1966163762 @default.
- W2013646237 cites W1969117624 @default.
- W2013646237 cites W1972962841 @default.
- W2013646237 cites W1974568730 @default.
- W2013646237 cites W1977504093 @default.
- W2013646237 cites W1978547782 @default.
- W2013646237 cites W1981232162 @default.
- W2013646237 cites W1988267408 @default.
- W2013646237 cites W1988900456 @default.
- W2013646237 cites W1992274603 @default.
- W2013646237 cites W1993738860 @default.
- W2013646237 cites W1993864575 @default.
- W2013646237 cites W1995987769 @default.
- W2013646237 cites W1997836836 @default.
- W2013646237 cites W1998846172 @default.
- W2013646237 cites W2002664542 @default.
- W2013646237 cites W2004459276 @default.
- W2013646237 cites W2005788509 @default.
- W2013646237 cites W2009351714 @default.
- W2013646237 cites W2009581739 @default.
- W2013646237 cites W2018172829 @default.
- W2013646237 cites W2018676703 @default.
- W2013646237 cites W2019097736 @default.
- W2013646237 cites W2020679328 @default.
- W2013646237 cites W2021978074 @default.
- W2013646237 cites W2022188871 @default.
- W2013646237 cites W2026370504 @default.
- W2013646237 cites W2026657651 @default.
- W2013646237 cites W2032698727 @default.
- W2013646237 cites W2034558506 @default.
- W2013646237 cites W2036399606 @default.
- W2013646237 cites W2036593842 @default.
- W2013646237 cites W2040481343 @default.
- W2013646237 cites W2041737563 @default.
- W2013646237 cites W2045830695 @default.
- W2013646237 cites W2050913592 @default.
- W2013646237 cites W2052309340 @default.
- W2013646237 cites W2052326665 @default.
- W2013646237 cites W2052370215 @default.
- W2013646237 cites W2055557113 @default.
- W2013646237 cites W2055583355 @default.
- W2013646237 cites W2057544210 @default.
- W2013646237 cites W2058920315 @default.
- W2013646237 cites W2059306569 @default.
- W2013646237 cites W2060017837 @default.
- W2013646237 cites W2060215608 @default.
- W2013646237 cites W2062779626 @default.
- W2013646237 cites W2063361978 @default.
- W2013646237 cites W2066055007 @default.
- W2013646237 cites W2066332825 @default.
- W2013646237 cites W2072971665 @default.
- W2013646237 cites W2073204556 @default.
- W2013646237 cites W2074613554 @default.
- W2013646237 cites W2076124785 @default.
- W2013646237 cites W2076843089 @default.
- W2013646237 cites W2077205550 @default.
- W2013646237 cites W2081027578 @default.
- W2013646237 cites W2081565848 @default.
- W2013646237 cites W2089608572 @default.
- W2013646237 cites W2092238715 @default.
- W2013646237 cites W2096795400 @default.
- W2013646237 cites W2100440853 @default.
- W2013646237 cites W2100959401 @default.
- W2013646237 cites W2104629556 @default.
- W2013646237 cites W2105879579 @default.
- W2013646237 cites W2106231921 @default.
- W2013646237 cites W2106774938 @default.
- W2013646237 cites W2108966130 @default.
- W2013646237 cites W2116166189 @default.
- W2013646237 cites W2117834701 @default.
- W2013646237 cites W2122100080 @default.
- W2013646237 cites W2122141896 @default.
- W2013646237 cites W2123107276 @default.
- W2013646237 cites W2123724498 @default.
- W2013646237 cites W2124166350 @default.
- W2013646237 cites W2128133969 @default.
- W2013646237 cites W2128398569 @default.
- W2013646237 cites W2129429612 @default.
- W2013646237 cites W2129522390 @default.
- W2013646237 cites W2130652515 @default.
- W2013646237 cites W2136471718 @default.
- W2013646237 cites W2137474088 @default.