Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013646710> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2013646710 endingPage "1148" @default.
- W2013646710 startingPage "1145" @default.
- W2013646710 abstract "Energy metabolism of murine FSaII foot tumors was studied by in vivo31P-MRS in C3Hf/Sed mice. Spectroscopy was performed following exposure to escalating doses of hydralazine (HYD) ip. At 0.25 mg/kg, HYD caused a 20% increase in PCr/Pi and had no significant effect on mean arterial blood pressure. HYD doses ≥2 mg/kg lead to hypotension which was associated with a decrease in PCr, NTP, pH, and an increase in Pi (p < 0.01 for control vs 10 mg/kg HYD). When mice were given ip injections of HYD (0.25, 1, 2 and 10 mg/kg) 10 min prior to whole body irradiation, spleen stem cell survival after 6 Gy was increased (2.19 colonies in control animals vs 6.74 colonies per spleen in animals treated with ≥2 mg/kg HYD), as was the dose (6.49 Gy [control] vs 9.00 Gy 110 mg/kg HYD]). The data provide evidence that PCr/Pi is a useful indicator of perfusion efficiency (and indirectly of hypoxic cell fraction) in FSaII tumors. These observations suggest that HYD may be a useful adjuvant for hyperthermic treatment of tumors and for potentiation of agents specifically toxic to hypoxic or nutrient-deprived cancer cells. HYD should be used with care in patients receiving radiation treatments or other therapies for which hypoxia can unfavorably affect treatment outcome." @default.
- W2013646710 created "2016-06-24" @default.
- W2013646710 creator A5012464988 @default.
- W2013646710 creator A5022434228 @default.
- W2013646710 creator A5040076986 @default.
- W2013646710 creator A5041868824 @default.
- W2013646710 creator A5042243800 @default.
- W2013646710 creator A5044584621 @default.
- W2013646710 creator A5078928066 @default.
- W2013646710 date "1989-05-01" @default.
- W2013646710 modified "2023-10-14" @default.
- W2013646710 title "Effects of hydralazine on in vivo tumor energy metabolism, hematopoietic radiation sensitivity, and cardiovascular parameters" @default.
- W2013646710 cites W1977923285 @default.
- W2013646710 cites W1994216439 @default.
- W2013646710 cites W2000900139 @default.
- W2013646710 cites W2013017643 @default.
- W2013646710 cites W2026786434 @default.
- W2013646710 cites W2036471991 @default.
- W2013646710 cites W2046749569 @default.
- W2013646710 cites W2048829754 @default.
- W2013646710 cites W2055908863 @default.
- W2013646710 cites W2077686877 @default.
- W2013646710 cites W2088679250 @default.
- W2013646710 cites W2121731045 @default.
- W2013646710 cites W2289249866 @default.
- W2013646710 cites W2335758191 @default.
- W2013646710 doi "https://doi.org/10.1016/0360-3016(89)90270-8" @default.
- W2013646710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2715061" @default.
- W2013646710 hasPublicationYear "1989" @default.
- W2013646710 type Work @default.
- W2013646710 sameAs 2013646710 @default.
- W2013646710 citedByCount "30" @default.
- W2013646710 crossrefType "journal-article" @default.
- W2013646710 hasAuthorship W2013646710A5012464988 @default.
- W2013646710 hasAuthorship W2013646710A5022434228 @default.
- W2013646710 hasAuthorship W2013646710A5040076986 @default.
- W2013646710 hasAuthorship W2013646710A5041868824 @default.
- W2013646710 hasAuthorship W2013646710A5042243800 @default.
- W2013646710 hasAuthorship W2013646710A5044584621 @default.
- W2013646710 hasAuthorship W2013646710A5078928066 @default.
- W2013646710 hasConcept C126322002 @default.
- W2013646710 hasConcept C134018914 @default.
- W2013646710 hasConcept C146957229 @default.
- W2013646710 hasConcept C150903083 @default.
- W2013646710 hasConcept C178790620 @default.
- W2013646710 hasConcept C185592680 @default.
- W2013646710 hasConcept C207001950 @default.
- W2013646710 hasConcept C2780521442 @default.
- W2013646710 hasConcept C2780931953 @default.
- W2013646710 hasConcept C540031477 @default.
- W2013646710 hasConcept C71924100 @default.
- W2013646710 hasConcept C7836513 @default.
- W2013646710 hasConcept C84393581 @default.
- W2013646710 hasConcept C86803240 @default.
- W2013646710 hasConcept C98274493 @default.
- W2013646710 hasConceptScore W2013646710C126322002 @default.
- W2013646710 hasConceptScore W2013646710C134018914 @default.
- W2013646710 hasConceptScore W2013646710C146957229 @default.
- W2013646710 hasConceptScore W2013646710C150903083 @default.
- W2013646710 hasConceptScore W2013646710C178790620 @default.
- W2013646710 hasConceptScore W2013646710C185592680 @default.
- W2013646710 hasConceptScore W2013646710C207001950 @default.
- W2013646710 hasConceptScore W2013646710C2780521442 @default.
- W2013646710 hasConceptScore W2013646710C2780931953 @default.
- W2013646710 hasConceptScore W2013646710C540031477 @default.
- W2013646710 hasConceptScore W2013646710C71924100 @default.
- W2013646710 hasConceptScore W2013646710C7836513 @default.
- W2013646710 hasConceptScore W2013646710C84393581 @default.
- W2013646710 hasConceptScore W2013646710C86803240 @default.
- W2013646710 hasConceptScore W2013646710C98274493 @default.
- W2013646710 hasIssue "5" @default.
- W2013646710 hasLocation W20136467101 @default.
- W2013646710 hasLocation W20136467102 @default.
- W2013646710 hasOpenAccess W2013646710 @default.
- W2013646710 hasPrimaryLocation W20136467101 @default.
- W2013646710 hasRelatedWork W117235360 @default.
- W2013646710 hasRelatedWork W1966234050 @default.
- W2013646710 hasRelatedWork W1966504330 @default.
- W2013646710 hasRelatedWork W1974041167 @default.
- W2013646710 hasRelatedWork W1979139803 @default.
- W2013646710 hasRelatedWork W2037631372 @default.
- W2013646710 hasRelatedWork W2040058909 @default.
- W2013646710 hasRelatedWork W2132898409 @default.
- W2013646710 hasRelatedWork W2171089442 @default.
- W2013646710 hasRelatedWork W2748952813 @default.
- W2013646710 hasVolume "16" @default.
- W2013646710 isParatext "false" @default.
- W2013646710 isRetracted "false" @default.
- W2013646710 magId "2013646710" @default.
- W2013646710 workType "article" @default.