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• W2013647501 abstract "The effects of variations in alpha-gene numbers on phenotypical expression of beta-thalassemia are assessed in 11 subjects of 8 families. The study indicates that coexistence of alpha-thalassemia (-alpha3.7/alpha alpha) decreases the HbF in IVSI-6 homozygote and in delta beta thalassemia trait and may ameliorate the disease in beta-thalassemia compound heterozygotes associated with one mild and one severe beta-thalassemia mutation. Coexistence of alpha-gene triplication is associated with an increase in HbF value and may increase the severity of beta-trait or beta-thalassemia intermedia. The effects of alpha-gene triplication on phenotypic expression of beta-thalassemia trait may not be uniformly observed in every subject affected with a similar genotype." @default.
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• W2013647501 date "1998-01-01" @default.
• W2013647501 modified "2023-10-17" @default.
• W2013647501 title "Effect of α-Gene Numbers on the Expression of β-Thalassemia intermedia, β-Thalassemia and (δβ)&#8304;-Thalassemia Traits" @default.
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• W2013647501 doi "https://doi.org/10.1159/000022792" @default.
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